Antimicrobial drug resistance is one of the major threats to global health. It has made
common infections increasingly difficult or impossible to treat, and leads to higher medical …

Escherichia coli is a versatile commensal and pathogenic member of the human microflora.
As the primary causative pathogen in urosepsis, E. coli places an immense burden on …

Scope These ESCMID guidelines address the targeted antibiotic treatment of third-
generation cephalosporin-resistant Enterobacterales (3GCephRE) and carbapenem …

Background There is a need for oral antibiotic agents that are effective against multidrug-
resistant gram-negative uropathogens. Tebipenem pivoxil hydrobromide is an orally …

Importance Cefepime/enmetazobactam is a novel β-lactam/β-lactamase inhibitor
combination and a potential empirical therapy for resistant gram-negative infections …

There is a clear need for simple resources to improve the quality of antibiotic prescribing
globally. The AWaRe book was designed as a tool to make the antibiotics section of the …

Importance The consumption of broad-spectrum drugs has increased as a consequence of
the spread of multidrug-resistant (MDR) Escherichia coli. Finding alternatives for these …

Dehydration strongly influences the stability of hydrate drug substances. Consequently, the
ability to predict dehydration of crystalline hydrate using the intermolecular interactions of …

Introduction Complicated urinary tract infections (cUTIs) entail diverse clinical conditions that
could be managed differently and not necessarily with premature empiric therapy. Since …

Multidrug-resistant (MDR) Pseudomonas aeruginosa presents a serious threat to public
health due to its widespread resistance to numerous antibiotics. P. aeruginosa commonly …