Reconsidering animal models used to study autism spectrum disorder: Current state and optimizing future

JL Silverman, A Thurm, SB Ethridge… - Genes, brain and …, 2022 - Wiley Online Library
Neurodevelopmental disorders (NDDs), including autism spectrum disorder (ASD) and
intellectual disability (ID), are pervasive, often lifelong disorders, lacking evidence‐based …

Hamster models of COVID-19 pneumonia reviewed: How human can they be?

AD Gruber, TC Firsching, J Trimpert… - Veterinary …, 2022 - journals.sagepub.com
The dramatic global consequences of the coronavirus disease 2019 (COVID-19) pandemic
soon fueled quests for a suitable model that would facilitate the development and testing of …

Planning experiments: Updated guidance on experimental design and analysis and their reporting III

MJ Curtis, SPH Alexander, G Cirino… - British Journal of …, 2022 - Wiley Online Library
Scientists who plan to publish in British Journal of Pharmacology (BJP) must read this article
before undertaking a study. This editorial provides guidance for the design of experiments …

Is the future of peer review automated?

R Schulz, A Barnett, R Bernard, NJL Brown… - BMC research …, 2022 - Springer
The rising rate of preprints and publications, combined with persistent inadequate reporting
practices and problems with study design and execution, have strained the traditional peer …

Aging-related cerebral microvascular changes visualized using ultrasound localization microscopy in the living mouse

MR Lowerison, NVC Sekaran, W Zhang, Z Dong… - Scientific reports, 2022 - nature.com
Aging-related cognitive decline is an emerging health crisis; however, no established
unifying mechanism has been identified for the cognitive impairments seen in an aging …

GSDME is related to prognosis and response to chemotherapy in oral cancer

S Wang, MJ Zhang, ZZ Wu, SW Zhu… - Journal of dental …, 2022 - journals.sagepub.com
Gasdermin E (GSDME), as the major executive protein of pyroptosis, has been considered
to be linked to antitumor immunity in recent years. However, the role of GSDME in oral …

sEH-derived metabolites of linoleic acid drive pathologic inflammation while impairing key innate immune cell function in burn injury

CB Bergmann, CB McReynolds… - Proceedings of the …, 2022 - National Acad Sciences
Fatty acid composition in the Western diet has shifted from saturated to polyunsaturated fatty
acids (PUFAs), and specifically to linoleic acid (LA, 18: 2), which has gradually increased in …

Non-responsiveness to cardioprotection by ischaemic preconditioning in Ossabaw minipigs with genetic predisposition to, but without the phenotype of the metabolic …

P Kleinbongard, HR Lieder, A Skyschally… - Basic research in …, 2022 - Springer
The translation of successful preclinical and clinical proof-of-concept studies on
cardioprotection to the benefit of patients with reperfused acute myocardial infarction has …

Microplastics Occurrence in the European Common Frog (Rana temporaria) from Cottian Alps (Northwest Italy)

P Pastorino, M Prearo, A Di Blasio, D Barcelò… - Diversity, 2022 - mdpi.com
Microplastics (MPs) pollution is arousing growing attention, yet knowledge about its
occurrence in amphibians is scant to date. With this study, we aimed to determine whether …

Gut-derived butyrate suppresses ocular surface inflammation

L Schaefer, H Hernandez, RA Coats, Z Yu… - Scientific reports, 2022 - nature.com
Dry eye is a common ocular inflammatory disorder characterized by tear film instability and
reduced tear production. There is increasing evidence that homeostasis of the ocular …