Why won't it stop? The dynamics of benzodiazepine resistance in status epilepticus

RJ Burman, RE Rosch, JM Wilmshurst, A Sen… - Nature Reviews …, 2022 - nature.com
Status epilepticus is a life-threatening neurological emergency that affects both adults and
children. Approximately 36% of episodes of status epilepticus do not respond to the current …

Diagnosis and management of seizures in the preterm infant

JDE Twanow - Seminars in Pediatric Neurology, 2022 - Elsevier
The risk of seizure is increased in premature neonates compared to full term infants, with a
distinct profile of etiologies, timing and character. Despite improvements in neonatal care …

Lacosamide decreases neonatal seizures without increasing apoptosis

RL Langton, S Sharma, GC Tiarks, AG Bassuk… - …, 2022 - Wiley Online Library
Objective Many seizing neonates fail to respond to first‐line anticonvulsant medications.
Phenobarbital, an allosteric modulator of γ‐aminobutyric acid type A (GABAA) receptors, has …

Using SuperClomeleon to measure changes in intracellular chloride during development and after early life stress

LJ Herstel, C Peerboom, S Uijtewaal, D Selemangel… - eneuro, 2022 - eneuro.org
Abstract Intraneuronal chloride concentrations ([Cl−] i) decrease during development
resulting in a shift from depolarizing to hyperpolarizing GABA responses via chloride …

[HTML][HTML] Современные аспекты противосудорожной фармакотерапии у новорожденных

ВЮ Перфильев, АГ Мирошниченко… - Российский вестник …, 2022 - cyberleninka.ru
Надлежащее лечение судорог у новорожденных важно для снижения частоты
долгосрочных неврологических нарушений. Ни одно из используемых в настоящее …

Repeated Sevoflurane Exposures in Neonatal Rats Increased the Brain Vulnerability to Future Stress Exposure and Resulted in Fear Extinction Deficit

B Chen, L Jiang, L Tan, W Zhou, Y Shang, F Li… - Neurotoxicity …, 2022 - Springer
Sevoflurane anesthesia during neonatal period was reported to sensitize the rodent animals
to stress later in life. The authors tested the hypothesis that repeated sevoflurane exposures …

Novel microglia-dependent mechanisms in the development and maintenance of chronic pain

S Tansley - 2022 - escholarship.mcgill.ca
Chronic pain is a debilitating condition that affects up to 20-25% of the population
worldwide. Given its complexity, it is notoriously difficult to treat. The rise in the opioid …

[PDF][PDF] Research Open

GPK Moyo, L Kuate, MF Mba, D Komba, AF Tchougene… - researchgate.net
Neonatal seizures are a spectacular but common sign in pediatrics which may be worrying
for parents and preoccupying for the physician. Although there have been considerable …

[PDF][PDF] Why Diazepam More than Other Benzodiazepines is Unsuitable for Neonates

GPK Moyo, CT Tchinda, MF Mba, D Komba, MP Bege… - globapc.com
For a good number of years, physician have learnt about the contraindication of diazepam
and perhaps benzodiazepines at large in the management of neonatal seizures. However …

[PDF][PDF] Why Diazepam More Than Other Benzodiazepines is Unsuitable for Neonates

KM GP, CT Tchinda, MF Mba, D Komba, MP Bege… - 2022 - suntextreviews.org
For a good number of years, physician have learnt about the contraindication of diazepam
and perhaps benzodiazepines at large in the management of neonatal seizures. However …