Pulmonary surfactant is critically important to prevent atelectasis by lowering the surface
tension of the alveolar lining liquid. While respiratory distress syndrome (RDS) is common in …

Amyloid formation is a pathological process associated with a wide range of degenerative
disorders, including Alzheimer's disease, Parkinson's disease, and diabetes mellitus type 2 …

Proteins can self-assemble into amyloid fibrils or amorphous aggregates and thereby cause
disease. Molecular chaperones can prevent both these types of protein aggregation, but to …

Genetic disorders of surfactant dysfunction result in significant morbidity and mortality,
among infants, children, and adults. Available medical interventions are limited, nonspecific …

Background Alveolar epithelial cell dysfunction plays an important role in the pathogenesis
of idiopathic pulmonary fibrosis (IPF), but remains incompletely understood. Some …

Surfactant protein C (SP-C) has several functions in pulmonary surfactant. These include the
transfer of lipids between different membrane structures, a role in surfactant recycling and …

Objective: To analyze the etiology of chest diffuse radiological changes (DRC) in children
older than 2 years. Methods A retrospective study was conducted on a primary cohort of …

The most common causes of childhood interstitial lung disease (chILD) are autosomal
recessive mutations in the gene encoding ATP Binding Cassette A3 (ABCA3) protein, a …