A detailed knowledge of the complex processes that make cells and organisms alive is
fundamental in order to understand diseases and to develop novel drugs and therapeutic …

The retinoblastoma protein (pRb) functions as a cell cycle regulator controlling G1 to S
phase transition and plays critical roles in tumour suppression. It is frequently inactivated in …

Hepatic osteodystrophy (HOD) is a metabolic bone disease that is often associated with
chronic liver disease and is marked by bone loss. Here, we demonstrate that hepatic …

Protein phosphorylation dynamically integrates environmental and cellular information to
control biological processes. Identifying functional phosphorylation amongst the thousands …

Human health is always under global spotlight, but now it suffers from severe environmental
issue and various diseases. Developing highly selective and effective extraction technique …

Metabolic reprogramming of cancer cells within the tumor microenvironment typically occurs
in response to increased nutritional, translation and proliferative demands. Altered lipid …

Post-translational modifications (PTMs) are closely linked to numerous diseases, playing a
significant role in regulating protein structures, activities, and functions. Therefore, the …

Selective inhibition of targeted protein kinases is an effective therapeutic approach for
treatment of human malignancies, which interferes phosphorylation of cellular substrates …

Liposomal delivery vehicles can dramatically enhance drug transport. However, their clinical
application requires enhanced control over content release at diseased sites. For this …

DNA repair confers the resistance of tumor cells to DNA‐damaging anticancer therapies,
while how reprogrammed metabolism in tumor cells contributes to such process remains …