High-frequency electrical stimulation attenuates neuronal release of inflammatory mediators and ameliorates neuropathic pain

H Yang, T Datta-Chaudhuri, SJ George, B Haider… - Bioelectronic …, 2022 - Springer
Background Neuroinflammation is an important driver of acute and chronic pain states.
Therefore, targeting molecular mediators of neuroinflammation may present an opportunity …

[HTML][HTML] Preconditioning by voluntary wheel running attenuates later neuropathic pain via Nrf2 antioxidant signaling in rats

SM Green-Fulgham, ME Harland, JB Ball, J Li… - Pain, 2022 - ncbi.nlm.nih.gov
Exercise can relieve established chronic pain in a range of preclinical models and clinical
conditions [13; 30; 68]. For example, preclinical and clinical studies have shown that …

Involvement of TLR2–TLR4, NLRP3, and IL-17 in pain induced by a novel Sprague-Dawley rat model of experimental autoimmune encephalomyelitis

AJ Kwilasz, MA Clements, TA Larson… - Frontiers in Pain …, 2022 - frontiersin.org
Up to 92% of patients suffering from multiple sclerosis (MS) express pain, most without
adequate treatment, and many report pain long before motor symptoms associated with MS …

Preconditioning by voluntary wheel running attenuates later neuropathic pain via nuclear factor E2–related factor 2 antioxidant signaling in rats

SM Green-Fulgham, ME Harland, JB Ball, J Li… - Pain, 2022 - journals.lww.com
Animal and human studies have shown that exercise prior to nerve injury prevents later
chronic pain, but the mechanisms of such preconditioning remain elusive. Given that …

Comparative effect of dense-and-disperse versus non-repetitive and non-sequential frequencies in electroacupuncture-induced analgesia in a rodent model of …

L Chao, ASR Goncalves, ACP Campos… - Acupuncture in …, 2022 - journals.sagepub.com
Background: Neuropathic pain (NP) is a complex disease that remains challenging to treat.
Low-frequency dense-and-disperse (DD) electroacupuncture (EA) has been used as …

Enhanced nociceptive behavior and expansion of associated primary afferents in a rabbit model of cerebral palsy

EJ Reedich, LT Genry, MA Singer… - Journal of …, 2022 - Wiley Online Library
Spastic cerebral palsy (CP) is a movement disorder marked by hypertonia and hyperreflexia;
the most prevalent comorbidity is pain. Since spinal nociceptive afferents contribute to both …

[图书][B] Effects of glucocorticoid receptor signaling on plasticity and recovery in central and peripheral nervous system injuries

KM Madalena - 2022 - search.proquest.com
The glucocorticoid receptor (GR), part of the nuclear receptor superfamily of transcription
factors, is ubiquitously expressed in all cell types and regulates cellular responses to …

Active targeting of cells by monosized protocells

CJ Brinker, K Butler, PN Durfee - US Patent 11,344,629, 2022 - Google Patents
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