Background: β-lactams remain the cornerstone of the empirical therapy to treat various
bacterial infections. This systematic review aimed to analyze the data describing the dosing …

Purpose Critically ill patients with preserved or increased renal function have been shown to
be at risk of underexposure to meropenem. Although many meropenem population …

Critically ill patients are characterized by substantial pathophysiological changes that alter
the pharmacokinetics (PK) of hydrophilic antibiotics, including carbapenems. Meropenem is …

Several pathophysiological changes can alter meropenem pharmacokinetics in critically ill
patients, thereby increasing the risk of subtherapeutic concentrations and affecting …

Routine clinical meropenem therapeutic drug monitoring data can be applied to model-
informed precision dosing. The current study aimed to evaluate the adequacy and predictive …

This prospective study aimed to explore the determinants of meropenem trough
concentration (Ctrough) in patients with bacterial pneumonia and to investigate the …

Purpose To evaluate the optimal dosing regimens of meropenem against extended-
spectrum beta-lactamase-producing Escherichia coli (ESBL E. coli) in critically ill patients …

Introduction The purpose of this study was to explore factors influencing meropenem
pharmacokinetics (PKs) in critically ill patients by developing a population PK model and to …

Sepsis, as defined by the Third International Consensus Definitions for Sepsis and Septic
Shock (Sepsis-3), is “life-threatening organ dysfunction caused by a dysregulated host …