Dose optimization of β-lactams antibiotics in pediatrics and adults: A systematic review
Background: β-lactams remain the cornerstone of the empirical therapy to treat various
bacterial infections. This systematic review aimed to analyze the data describing the dosing …
bacterial infections. This systematic review aimed to analyze the data describing the dosing …
Meropenem target attainment and population pharmacokinetics in critically ill septic patients with preserved or increased renal function
M Gijsen, O Elkayal, P Annaert… - Infection and Drug …, 2022 - Taylor & Francis
Purpose Critically ill patients with preserved or increased renal function have been shown to
be at risk of underexposure to meropenem. Although many meropenem population …
be at risk of underexposure to meropenem. Although many meropenem population …
Optimizing meropenem in highly resistant Klebsiella pneumoniae environments: population pharmacokinetics and dosing simulations in critically ill patients
AQ Truong, XC Dao, DH Vu, HA Nguyen… - Antimicrobial Agents …, 2022 - Am Soc Microbiol
Critically ill patients are characterized by substantial pathophysiological changes that alter
the pharmacokinetics (PK) of hydrophilic antibiotics, including carbapenems. Meropenem is …
the pharmacokinetics (PK) of hydrophilic antibiotics, including carbapenems. Meropenem is …
Population pharmacokinetics/pharmacodynamics and clinical outcomes of meropenem in critically ill patients
A Boonpeng, S Jaruratanasirikul… - Antimicrobial Agents …, 2022 - Am Soc Microbiol
Several pathophysiological changes can alter meropenem pharmacokinetics in critically ill
patients, thereby increasing the risk of subtherapeutic concentrations and affecting …
patients, thereby increasing the risk of subtherapeutic concentrations and affecting …
External evaluation of population pharmacokinetic models to inform precision dosing of meropenem in critically ill patients
N Yang, J Wang, Y Xie, J Ding, C Wu, J Liu… - Frontiers in …, 2022 - frontiersin.org
Routine clinical meropenem therapeutic drug monitoring data can be applied to model-
informed precision dosing. The current study aimed to evaluate the adequacy and predictive …
informed precision dosing. The current study aimed to evaluate the adequacy and predictive …
C/MIC> 4: a potential instrument to predict the efficacy of meropenem
Y Zhao, C Xiao, J Hou, J Wu, Y Xiao, B Zhang… - Antibiotics, 2022 - mdpi.com
This prospective study aimed to explore the determinants of meropenem trough
concentration (Ctrough) in patients with bacterial pneumonia and to investigate the …
concentration (Ctrough) in patients with bacterial pneumonia and to investigate the …
The Evaluation of Meropenem Dosing Regimens Against ESBL-Producing Escherichia coli in ICU Patients Using Monte Carlo Simulation
EE Win, KW Htun, P Tragulpiankit… - Infection and Drug …, 2022 - Taylor & Francis
Purpose To evaluate the optimal dosing regimens of meropenem against extended-
spectrum beta-lactamase-producing Escherichia coli (ESBL E. coli) in critically ill patients …
spectrum beta-lactamase-producing Escherichia coli (ESBL E. coli) in critically ill patients …
Identification of factors affecting meropenem pharmacokinetics in critically ill patients: impact of inflammation on clearance
Y Niibe, T Suzuki, S Yamazaki, M Uchida… - Journal of Infection and …, 2022 - Elsevier
Introduction The purpose of this study was to explore factors influencing meropenem
pharmacokinetics (PKs) in critically ill patients by developing a population PK model and to …
pharmacokinetics (PKs) in critically ill patients by developing a population PK model and to …
[PDF][PDF] Anti-infective Therapy in Sepsis and Septic Shock
J Maker - accp.com
Sepsis, as defined by the Third International Consensus Definitions for Sepsis and Septic
Shock (Sepsis-3), is “life-threatening organ dysfunction caused by a dysregulated host …
Shock (Sepsis-3), is “life-threatening organ dysfunction caused by a dysregulated host …