Ion channels play a central role in the regulation of nearly every cellular process. Dating
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …

Neurodegenerative disorders are currently incurable devastating diseases which are
characterized by the slow and progressive loss of neurons in specific brain regions …

How do neurons match generation of adenosine triphosphate by mitochondria to the
bioenergetic demands of regenerative activity? Although the subject of speculation, this …

Dopamine metabolism, alpha-synuclein pathology, and iron homeostasis have all been
implicated as potential contributors to the unique vulnerability of substantia nigra …

There are 400–500 thousand dopaminergic cells within each side of the human substantia
nigra pars compacta (SNpc) making them a minuscule portion of total brain mass. These tiny …

Oxidative stress and neuroinflammation are common bases for disease onset and
progression in many neurodegenerative diseases. In Parkinson disease, which is …

Mutations in the SNCA gene cause autosomal dominant Parkinson's disease (PD), with loss
of dopaminergic neurons in the substantia nigra, and aggregation of α-synuclein. The …

As the ability to capture single-cell expression profiles has grown in recent years,
neuroscientists studying a wide gamut of brain regions have discovered remarkable …

The low-threshold L-type calcium channel Cav1. 3 accelerates the pacemaker rate in the
heart, but its functional role for the extended dynamic range of neuronal firing is still …

Parkinson's disease (PD) is the most common neurodegenerative movement disorder, and
motor dysfunction has been attributed to loss of dopaminergic neurons. However, motor …