Abstract Parkinson's disease (PD), the second most common progressive
neurodegenerative disease, develops and progresses for 10–15 years before the clinical …

Intracellular accumulation of abnormal proteins with conformational changes is the defining
neuropathological feature of neurodegenerative diseases. The pathogenic proteins that …

Considerable evidence supports the release of pathogenic aggregates of the neuronal
protein α-Synuclein (αSyn) into the extracellular space. While this release is proposed to …

Abstract α-synuclein misfolding and aggregation into fibrils is a common feature of α-
synucleinopathies, such as Parkinson's disease, in which α-synuclein fibrils are a …

Intraneuronal inclusions of misfolded α-synuclein (α-syn) and prion-like spread of the
pathologic α-syn contribute to progressive neuronal death in Parkinson's disease (PD) …

α-Synuclein (α-Syn) is the major protein component of Lewy bodies, a key pathological
feature of Parkinson's disease (PD). The manganese ion Mn 2+ has been identified as an …

Objective The purpose of this study was to determine the sensitivity and specificity of α‐
synuclein seed amplification assay (αSyn‐SAA) in antemortem and postmortem …

Diseases in the central nervous system (CNS) are often difficult to treat. Antibody-and
protein-based therapeutics hold huge promises in CNS disease treatment. However …

Fibrillar aggregates of the α-synuclein (αS) protein are the hallmark of Parkinson's Disease
and related neurodegenerative disorders. Characterization of the effects of mutations and …

Aggregation of α-synuclein (α-syn) into amyloid fibrils is closely associated with Parkinson's
disease (PD). Familial mutations or posttranslational truncations in α-syn are known as risk …