Cross disorder comparisons of brain structure in schizophrenia, bipolar disorder, major depressive disorder, and 22q11. 2 deletion syndrome: a review of ENIGMA …

EJ Cheon, CE Bearden, D Sun… - Psychiatry and …, 2022 - Wiley Online Library
This review compares the main brain abnormalities in schizophrenia (SZ), bipolar disorder
(BD), major depressive disorder (MDD), and 22q11. 2 Deletion Syndrome (22q11DS) …

A systematic review and meta-analysis of structural and functional brain alterations in individuals with genetic and clinical high-risk for psychosis and bipolar disorder

LP Luna, J Radua, L Fortea, G Sugranyes… - Progress in Neuro …, 2022 - Elsevier
Neuroimaging findings in people at either genetic risk or at clinical high-risk for psychosis
(CHR-P) or bipolar disorder (CHR-B) remain unclear. A meta-analytic review of whole-brain …

Mendelian randomization analyses support causal relationships between brain imaging-derived phenotypes and risk of psychiatric disorders

J Guo, K Yu, SS Dong, S Yao, Y Rong, H Wu… - Nature …, 2022 - nature.com
Observational studies have reported the correlations between brain imaging-derived
phenotypes (IDPs) and psychiatric disorders; however, whether the relationships are causal …

A meta‐analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the …

BA Gutman, TGM Van Erp, K Alpert… - Human brain …, 2022 - Wiley Online Library
Schizophrenia is associated with widespread alterations in subcortical brain structure. While
analytic methods have enabled more detailed morphometric characterization, findings are …

What we learn about bipolar disorder from large‐scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group

CRK Ching, DP Hibar, TP Gurholt, A Nunes… - Human brain …, 2022 - Wiley Online Library
MRI‐derived brain measures offer a link between genes, the environment and behavior and
have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of …

[HTML][HTML] Gray matter abnormalities and associated familial risk endophenotype in individuals with first-episode bipolar disorder: evidence from whole-brain voxel-wise …

J Long, K Qin, Y Wu, L Li, J Zhou - Asian Journal of Psychiatry, 2022 - Elsevier
Gray matter abnormalities have been widely reported in individuals with and at familial risk
for bipolar disorder (BD). However, inconsistent findings were reported, and whether shared …

[HTML][HTML] Cortical and subcortical neuroanatomical signatures of schizotypy in 3004 individuals assessed in a worldwide ENIGMA study

M Kirschner, B Hodzic-Santor, M Antoniades… - Molecular …, 2022 - nature.com
Neuroanatomical abnormalities have been reported along a continuum from at-risk stages,
including high schizotypy, to early and chronic psychosis. However, a comprehensive …

ENIGMA brain injury: Framework, challenges, and opportunities

EL Dennis, D Baron, B Bartnik‐Olson… - Human brain …, 2022 - Wiley Online Library
Traumatic brain injury (TBI) is a major cause of disability worldwide, but the heterogeneous
nature of TBI with respect to injury severity and health comorbidities make patient outcome …

[HTML][HTML] Genetic and environment effects on structural neuroimaging endophenotype for bipolar disorder: a novel molecular approach

B Hu, J Cha, JM Fullerton, S Hesam-Shariati… - Translational …, 2022 - nature.com
We investigated gene–environment effects on structural brain endophenotype in bipolar
disorder (BD) using a novel method of combining polygenic risk scores with epigenetic …

Genomic and neuroimaging approaches to bipolar disorder

MO Kohshour, S Papiol, CRK Ching, TG Schulze - BJPsych open, 2022 - cambridge.org
Background To date, besides genome-wide association studies, a variety of other genetic
analyses (eg polygenic risk scores, whole-exome sequencing and whole-genome …