Dietary restriction with adequate nutrition is the gold standard for delaying ageing and
extending healthspan and lifespan in diverse species, including rodents and non-human …

Sex differences in aging occur in many animal species, and they include sex differences in
lifespan, in the onset and progression of age‐associated decline, and in physiological and …

The proportion of humans suffering from age‐related diseases is increasing around the
world, and creative solutions are needed to promote healthy longevity. Recent work has …

Aging is a complex process indicated by low energy levels, declined physiological activity,
stress induced loss of homeostasis leading to the risk of diseases and mortality. Recent …

Aging constitutes progressive physiological changes in an organism. These changes alter
the normal biological functions, such as the ability to manage metabolic stress, and …

The aging brain is characterized by progressive increases in neuroinflammation and central
insulin resistance, which contribute to neurodegenerative diseases and cognitive …

The strong evidence of metformin use in subjects affected by type 2 diabetes (T2DM) on
health outcomes, together with data from pre-clinical studies, has led the gerontological …

Circular RNAs (circRNAs) are a class of covalently circular noncoding RNAs that have been
extensively studied in recent years. Aging is a process related to functional decline that is …

The conserved neurotransmitter serotonin has been shown to be an important modulator of
lifespan in specific nutritional contexts; however, it remained unclear how serotonin …

Downregulation of mTOR (mechanistic target of rapamycin) can extend lifespan in multiple
species, including mice. Growth hormone receptor knockout mice (GHRKO) and Snell dwarf …