The tumor protein TP53 gene, encoding the cellular tumor antigen p53, is the single most
frequently mutated gene in human cancers. p53 plays a central role in responding to DNA …

Analogies between placentation, in particular the behavior of trophoblast cells, and cancer
have been noted since the beginning of the twentieth century. To what degree these can be …

Mammals differ more than 100-fold in maximum lifespan. Here, we conducted comparative
transcriptomics on 26 species with diverse lifespans. We identified thousands of genes with …

Cancer is among the most common causes of death for dogs (and cats) and humans in the
developed world, even though it is uncommon in wildlife and other domestic animals. We …

Aging is a complex process indicated by low energy levels, declined physiological activity,
stress induced loss of homeostasis leading to the risk of diseases and mortality. Recent …

The p53 tumor suppressor is a transcription factor with roles in cell development, apoptosis,
oncogenesis, aging, and homeostasis in response to stresses and infections. p53 is tightly …

Evolving to become bigger and/or longer lived should increase cancer susceptibility, but this
predicted increase is not observed, a contradiction named Peto's paradox. A solution is that …

Within primates, the great apes are outliers both in terms of body size and lifespan, since
they include the largest and longest-lived species in the order. Yet, the molecular bases …

The tumor suppressor p53 is thought to play a key role in the maintenance of cell size and
homeostasis, but relatively little is known about its role in skeletal muscle. Based on its …

The number of (TTAGGG) n repeats at the ends of chromosomes is highly variable between
individual chromosomes, between different cells and between species. Progressive loss of …