Background: Delineation of the epileptogenic zone (EZ) is crucial during resective surgery in
patients with epilepsy. In recent years, high-frequency oscillations, including fast ripples and …

Abstract Interictal High Frequency Oscillations (HFO) are measurable in scalp EEG. This
development has aroused interest in investigating their potential as biomarkers of …

Objective The integration of high‐frequency oscillations (HFOs; ripples [80–250 Hz], fast
ripples [250–500 Hz]) in epilepsy evaluation is hampered by physiological HFOs, which …

The epileptic network hypothesis and epileptogenic zone hypothesis are two theories of
ictogenesis. The network hypothesis posits that coordinated activity among interconnected …

Epileptiform spikes are used to localize epileptogenic brain tissue. The mechanisms that
spontaneously trigger epileptiform discharges are not yet elucidated. Pathological fast ripple …

Intracranially recorded interictal high-frequency oscillations have been proposed as a
promising spatial biomarker of the epileptogenic zone. However, its visual verification is time …

Objective We hypothesized that spatio-temporal dynamics of interictal spikes reflect the
extent and stability of epileptic sources and determine surgical outcome. Methods We …

In drug-resistant focal epilepsy, interictal high-frequency oscillations (HFOs) recorded from
intracranial EEG (iEEG) may provide clinical information for delineating epileptogenic brain …

Sleep recordings are an integral part of presurgical evaluation in drug-resistant focal
epilepsy. Physiological network functioning is substantially different between wakefulness …

Epilepsy surgery can potentially cure or substantially improve drug-resistant focal epilepsy.
1 However, for some people, surgery might not be successful, or could be precluded …