Polyphenols: Chemoprevention and therapeutic potentials in hematological malignancies
OO Izuegbuna - Frontiers in Nutrition, 2022 - frontiersin.org
Polyphenols are one of the largest plant-derived natural product and they play an important
role in plants' defense as well as in human health and disease. A number of them are …
role in plants' defense as well as in human health and disease. A number of them are …
PI3K targeting in non-solid cancer
HN Kim, H Ogana, V Sanchez, C Nichols… - PI3K and AKT Isoforms in …, 2022 - Springer
Despite the therapeutic progress, relapse remains a major problem in the treatment of acute
lymphoblastic leukemia (ALL). Most leukemia cells that survive chemotherapy are found in …
lymphoblastic leukemia (ALL). Most leukemia cells that survive chemotherapy are found in …
Targeting the NOTCH1-MYC-CD44 axis in leukemia-initiating cells in T-ALL
Abstract The NOTCH1-MYC-CD44 axis integrates cell-intrinsic and extrinsic signaling to
ensure the persistence of leukemia-initiating cells (LICs) in T-cell acute lymphoblastic …
ensure the persistence of leukemia-initiating cells (LICs) in T-cell acute lymphoblastic …
MicroRNAs as modulators of the immune response in T-cell acute lymphoblastic leukemia
Acute lymphoblastic leukaemia (ALL) is an aggressive haematological tumour driven by the
malignant transformation and expansion of B-cell (B-ALL) or T-cell (T-ALL) progenitors. The …
malignant transformation and expansion of B-cell (B-ALL) or T-cell (T-ALL) progenitors. The …
[HTML][HTML] DT7 peptide-modified lecithin nanoparticles co-loaded with γ-secretase inhibitor and dexamethasone efficiently inhibit T-cell acute lymphoblastic leukemia …
Y Zhou, L Guan, W Li, R Jia, L Jia, Y Zhang, X Wen… - Cancer Letters, 2022 - Elsevier
T-cell acute lymphoblastic leukemia (T-ALL) is a serious hematologic malignancy and
glucocorticoid resistance is the main recurrent cause for a high relapsed and death rate …
glucocorticoid resistance is the main recurrent cause for a high relapsed and death rate …
Mechanism of IDH1-R132H mutation in T cell acute lymphoblastic leukemia mouse model via the Notch1 pathway
Y Liu, B Fang, X Feng, Y Jiang, Y Zeng, J Jiang - Tissue and Cell, 2022 - Elsevier
T-cell acute lymphoblastic leukemia (T-ALL) is a clonal malignant disease. Isocitrate
Dehydrogenase 1-R123 (IDH1-R132 H) is related to T-ALL progression. This study explored …
Dehydrogenase 1-R123 (IDH1-R132 H) is related to T-ALL progression. This study explored …
miRNA Pattern in Hypoxic Microenvironment of Kidney Cancer—Role of PTEN
A Majewska, K Brodaczewska, A Filipiak-Duliban… - Biomolecules, 2022 - mdpi.com
MicroRNAs are post-transcriptional regulators of gene expression, and disturbances of their
expression are the basis of many pathological states, including cancers. The miRNA pattern …
expression are the basis of many pathological states, including cancers. The miRNA pattern …
Single Cell RNA Sequencing Driven Characterization of Pediatric Mixed Phenotype Acute Leukemia
Background Mixed phenotype acute leukemia (MPAL) is a rare subgroup of leukemia
characterized by blast cells that display both myeloid and lymphoid lineage features, making …
characterized by blast cells that display both myeloid and lymphoid lineage features, making …
ETS1 Promotes Context-Dependent Activation of Notch Signals in T-Cell Leukemia
A McCarter - 2022 - deepblue.lib.umich.edu
Notch is a signaling pathway involved in cellular growth and development. Aberrant
activation of the Notch pathway is prevalent in cancer, including more than 60% of cases of …
activation of the Notch pathway is prevalent in cancer, including more than 60% of cases of …