Synaptopathies are a class of neurodevelopmental disorders caused by modification in
genes coding for synaptic proteins. These proteins oversee the process of …

With the development and application of next‐generation sequencing technology, the
aetiological diagnosis of genetic epilepsy is rapidly becoming easier and less expensive …

Kv3 channels have distinctive gating kinetics tailored for rapid repolarization in fast-spiking
neurons. Malfunction of this process due to genetic variants in the KCNC1 gene causes …

Which cell types constitute brain circuits is a fundamental question, but establishing the
correspondence across cellular data modalities is challenging. Bio-realistic models allow …

Kv3 channels enable neurons to fire at very high frequencies (> 100 Hz) which is
fundamental to brain development and our ability to make sense of the world at large. Cryo …

Kv3 ion-channels constitute a class of functionally distinct voltage-gated ion channels
characterized by their ability to fire at a high frequency. Several disease relevant mutants …

PURPOSE OF REVIEW This article reviews the clinical features, typical EEG findings,
treatment, prognosis, and underlying molecular etiologies of the more common genetic …

Neuraminidase 1 (NEU1) is considered to be the most abundant and ubiquitous mammalian
enzyme, with a broad tissue distribution. It plays a crucial role in a variety of cellular …

Background and Objectives KCNC2 encodes Kv3. 2, a member of the Shaw-related (Kv3)
voltage-gated potassium channel subfamily, which is important for sustained high-frequency …

Abstract Parvalbumin-expressing (PV+) interneurons in the sensory cortex form powerful
inhibitory synapses on the perisomatic compartments and axon initial segments of excitatory …