Derivation of prognostic contextual histopathological features from whole-slide images of tumours via graph deep learning

Y Lee, JH Park, S Oh, K Shin, J Sun, M Jung… - Nature Biomedical …, 2022 - nature.com
Methods of computational pathology applied to the analysis of whole-slide images (WSIs) do
not typically consider histopathological features from the tumour microenvironment. Here …

[HTML][HTML] A proteogenomic analysis of clear cell renal cell carcinoma in a Chinese population

Y Qu, J Feng, X Wu, L Bai, W Xu, L Zhu, Y Liu… - Nature …, 2022 - nature.com
Clear cell renal cell carcinoma (ccRCC) is a common and aggressive subtype of renal
cancer. Here we conduct a comprehensive proteogenomic analysis of 232 tumor and …

French AFU Cancer Committee Guidelines-update 2022-2024: management of kidney cancer

P Bigot, P Barthelemy, R Boissier, ZE Khene… - Progrès en Urologie, 2022 - Elsevier
Aim To update the recommendations for the management of kidney cancers. Methods A
systematic review of the literature was conducted from 2015 to 2022. The most relevant …

[HTML][HTML] Chromophobe renal cell carcinoma: Novel molecular insights and clinicopathologic updates

R Alaghehbandan, CG Przybycin, V Verkarre… - Asian Journal of …, 2022 - Elsevier
Chromophobe renal cell carcinoma (ChRCC) is the third most common renal cell carcinoma
(RCC) subtype, which predominantly occurs in sporadic setting. ChRCCs are considered to …

CT-based radiomics stratification of tumor grade and TNM stage of clear cell renal cell carcinoma

NL Demirjian, BA Varghese, SY Cen, DH Hwang… - European …, 2022 - Springer
Objectives To evaluate the utility of CT-based radiomics signatures in discriminating low-
grade (grades 1–2) clear cell renal cell carcinomas (ccRCC) from high-grade (grades 3–4) …

[HTML][HTML] Long-term outcomes with nivolumab plus ipilimumab versus sunitinib in first-line treatment of patients with advanced sarcomatoid renal cell carcinoma

BI Rini, S Signoretti, TK Choueiri… - … for immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Background Patients with advanced renal cell carcinoma with sarcomatoid features (sRCC)
have a poor prognosis and limited therapeutic options. First-line nivolumab plus ipilimumab …

Machine learning-based pathomics signature could act as a novel prognostic marker for patients with clear cell renal cell carcinoma

S Chen, L Jiang, F Gao, E Zhang, T Wang… - British Journal of …, 2022 - nature.com
Background Traditional histopathology performed by pathologists through naked eyes is
insufficient for accurate survival prediction of clear cell renal cell carcinoma (ccRCC) …

Clinical significance of novel DNA methylation biomarkers for renal clear cell carcinoma

R Kubiliūtė, K Žukauskaitė, A Žalimas, A Ulys… - Journal of Cancer …, 2022 - Springer
Objective Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney tumor
characterized by the highest mortality rate of the genitourinary cancers, and, therefore, new …

[HTML][HTML] Hyperpolarized 13C-Pyruvate Metabolism as a Surrogate for Tumor Grade and Poor Outcome in Renal Cell Carcinoma—A Proof of Principle Study

S Ursprung, R Woitek, MA McLean, AN Priest… - Cancers, 2022 - mdpi.com
Simple Summary We evaluated renal cancer with varying aggressive appearances on
histology, using an emerging form of non-invasive metabolic MRI. This imaging technique …

[HTML][HTML] Papillary renal cell carcinoma: a single institutional study of 199 cases addressing classification, clinicopathologic and molecular features, and treatment …

P Murugan, L Jia, RG Dinatale, M Assel, N Benfante… - Modern Pathology, 2022 - Elsevier
The morphologic spectrum of type 1 papillary renal cell carcinoma (PRCC) is not well-
defined, since a significant proportion of cases have mixed type 1 and 2 histology. We …