COVID-19 coagulopathy: from pathogenesis to treatment

T Alnima, MMG Mulder, BCT van Bussel… - Acta …, 2022 - karger.com
Abstract Coronavirus disease 2019 (COVID-19) has emerged as a pandemic at the end of
2019 and continues to exert an unfavorable worldwide health impact on a large proportion …

Persistent lung injury and prothrombotic state in long COVID

M Xiang, H Jing, C Wang, VA Novakovic… - Frontiers in …, 2022 - frontiersin.org
Lung injury may persist during the recovery period of COVID-19 as shown through imaging,
six-minute walk, and lung function tests. The pathophysiological mechanisms leading to …

[HTML][HTML] Good practice statements for antithrombotic therapy in the management of COVID‐19: guidance from the SSC of the ISTH

AC Spyropoulos, JM Connors, JD Douketis… - Journal of Thrombosis …, 2022 - Elsevier
Despite the emergence of high quality randomized trial data with the use of antithrombotic
agents to reduce the risk of thromboembolism, end‐organ failure, and possibly mortality in …

Use of N-Acetylcysteine at high doses as an oral treatment for patients hospitalized with COVID-19

JL Izquierdo, JB Soriano, Y González… - Science …, 2022 - journals.sagepub.com
Infection by SARS-CoV-2 causing coronavirus disease 2019 (COVID-19) can be associated
with serious and life-threatening conditions, including acute respiratory distress syndrome …

A phase 2 single center open label randomised control trial for convalescent plasma therapy in patients with severe COVID-19

Y Ray, SR Paul, P Bandopadhyay, R D'Rozario… - Nature …, 2022 - nature.com
A single center open label phase 2 randomised control trial (Clinical Trial Registry of India
No. CTRI/2020/05/025209) was done to assess clinical and immunological benefits of …

COVID-19 and the immune response: A multi-phasic approach to the treatment of covid-19

T Sapir, Z Averch, B Lerman, A Bodzin… - International Journal of …, 2022 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a viral agent that causes
Coronavirus disease 2019 (COVID-19), a disease that causes flu-like symptoms that, when …

[HTML][HTML] Heparanase as active player in endothelial glycocalyx remodeling

V Masola, N Greco, G Gambaro, M Franchi, M Onisto - Matrix Biology Plus, 2022 - Elsevier
The surface of all animal cells is coated with a layer of carbohydrates linked in various ways
to the outer side of the plasma membrane. These carbohydrates are mainly bound to …

Incidence, risk factors, and clinical impact of major bleeding in hospitalized patients with COVID-19: a sub-analysis of the CLOT-COVID Study

J Nakamura, I Tsujino, S Yachi, M Takeyama… - Thrombosis journal, 2022 - Springer
Background The coronavirus disease 2019 (COVID-19) causes extensive coagulopathy and
a potential benefit of anticoagulation therapy has been documented for prevention of …

Factors associated with length of hospital stay among COVID-19 patients in Saudi Arabia: a retrospective study during the first pandemic wave

AK Alahmari, ZS Almalki, AA Albassam, MM Alsultan… - Healthcare, 2022 - mdpi.com
The COVID-19 pandemic severely affected healthcare systems and tested their
preparedness. To date, the length of hospital stay (LoHS) and its factors among COVID-19 …

Targeting of Glycosaminoglycans in genetic and inflammatory Airway Disease

R Caird, M Williamson, A Yusuf, D Gogoi… - International Journal of …, 2022 - mdpi.com
In the lung, glycosaminoglycans (GAGs) are dispersed in the extracellular matrix (ECM)
occupying the interstitial space between the capillary endothelium and the alveolar …