Nucleosome recognition and DNA distortion by the Chd1 remodeler in a nucleotide-free state

IM Nodelman, S Das, AM Faustino, SD Fried… - Nature structural & …, 2022 - nature.com
Chromatin remodelers are ATP-dependent enzymes that reorganize nucleosomes within all
eukaryotic genomes. Here we report a complex of the Chd1 remodeler bound to a …

Crystal structure of the core module of the yeast Paf1 complex

F Chen, B Liu, J Zeng, L Guo, X Ge, W Feng… - Journal of Molecular …, 2022 - Elsevier
The highly conserved multifunctional polymerase-associated factor 1 (Paf1) complex
(PAF1C), which consists of five core subunits: Ctr9, Paf1, Leo1, Cdc73, and Rtf1, acts as a …

The PAF1 complex cell autonomously promotes oogenesis in Caenorhabditis elegans

Y Kubota, N Ota, H Takatsuka, T Unno, S Onami… - Genes to …, 2022 - Wiley Online Library
The RNA polymerase II‐associated factor 1 complex (PAF1C) is a protein complex that
consists of LEO1, RTF1, PAF1, CDC73, and CTR9, and has been shown to be involved in …

Spt6 directly interacts with Cdc73 and is required for Paf1C recruitment to active genes

MA Ellison, MS Blacksmith, S Namjilsuren, MK Shirra… - bioRxiv, 2022 - biorxiv.org
Paf1C is a conserved transcription elongation factor that regulates transcription elongation
efficiency, facilitates co-transcriptional histone modifications, and impacts molecular …

Using multi-omic approaches to identify modulators of Alzheimer's disease risk

M Seto - 2022 - search.proquest.com
Alzheimer's disease (AD) is a neurodegenerative disorder that is characterized by
neurodegeneration, memory loss and cognitive impairment. Sporadic late-onset AD is the …

[PDF][PDF] A novel pathway of DNA double-strand break

Z Ying - 2022 - ir.library.osaka-u.ac.jp
Meiotic double-strand break (DSB) formation at early prophase I, which initiates homologous
recombination, is essential for the meiosis. In budding yeast meiosis, Spo11, a …

[图书][B] Elucidating novel gene regulatory functions of the transcription elongation factor Rtf1

JJ Chen - 2022 - search.proquest.com
Abstract RNA polymerase II (RNAPII) transcription is coupled to co-transcriptional processes
that regulate numerous aspects of genomic function, including histone post-translational …