Radiotherapy (RT) is a highly effective anticancer treatment that is delivered to more than
half of all patients with cancer. In addition to the well-documented direct cytotoxic effects, RT …

Purpose The abscopal effect is defined when a form of local therapy causes tumor
regression of both the target lesion and any untreated tumors. Herein cases of the abscopal …

Radiotherapy is adopted to obliterate multiple malignant tumors clinically, which might also
induce antitumor immune response. However, traditional radiotherapy is not enough to …

Metastasis is the predominant cause of cancer deaths due to solid organ malignancies;
however, anticancer drugs are not effective in treating metastatic cancer. Here we report a …

Proliferating cells regularly experience replication stress caused by spontaneous DNA
damage that results from endogenous reactive oxygen species (ROS), DNA sequences that …

Strong rationale and a growing number of preclinical and clinical studies support combining
radiotherapy and immunotherapy to improve patient outcomes. However, several critical …

The role of Heat Shock Proteins (HSPs) is a “double-edged sword” with regards to tumors.
The location and interactions of HSPs determine their pro-or antitumor activity. The present …

Although initial surgical excision cures 95% of patients, a minority of cutaneous squamous
cell carcinomas (cSCCs) are judged to be unresectable, either locally advanced or with …

Esophageal cancer (EC) is one of the most common cancers worldwide, especially in China.
Despite therapeutic advances, the 5-year survival rate of EC is still dismal. For patients with …

Background Stereotactic body radiation therapy (SBRT) and radiofrequency ablation (RFA)
are recommended for patients with inoperable early-stage non-small cell lung cancer …