Heterocycle-based multicomponent reactions in drug discovery: from hit finding to rational design
P Nadal Rodríguez, O Ghashghaei, A Bagán… - Biomedicines, 2022 - mdpi.com
In the context of the structural complexity necessary for a molecule to selectively display a
therapeutical action and the requirements for suitable pharmacokinetics, a robust synthetic …
therapeutical action and the requirements for suitable pharmacokinetics, a robust synthetic …
Intramolecular activation of strong Si–O bonds by gold (i): regioselective synthesis of 3-bromo-2-silylbenzofurans
P Fernández-Canelas, R Miguélez, E Rubio… - Chemical …, 2022 - pubs.rsc.org
The high reactivity of gold-vinylidene complexes, generated in situ by [1, 2]-bromine shift
from the corresponding 1-bromoalkynes, allows the activation of one of the strongest bonds …
from the corresponding 1-bromoalkynes, allows the activation of one of the strongest bonds …
Discovery of Tryptophan‐tetrahydroisoquinoline Derivatives as Multifunctional Agents for Treatment of Alzheimer's Disease
X Lu, Y Liu, N Qin, C Du, Y Hu… - Chinese Journal of …, 2022 - Wiley Online Library
Comprehensive Summary The cholinesterases are essential targets implicated in the
pathogenesis of Alzheimer's disease (AD). We have identified tryptophan …
pathogenesis of Alzheimer's disease (AD). We have identified tryptophan …
An Imidazoline 2 Receptor Ligand Relaxes Mouse Aorta via Off-Target Mechanisms Resistant to Aging
F Jiménez-Altayó, A Cabrera, A Bagán… - Frontiers in …, 2022 - frontiersin.org
Imidazoline receptors (IR) are classified into three receptor subtypes (I1R, I2R, and I3R) and
previous studies showed that regulation of I2R signaling has neuroprotective potential. In …
previous studies showed that regulation of I2R signaling has neuroprotective potential. In …
Insights into the Pharmacokinetics and In Vitro Cell-Based Studies of the Imidazoline I2 Receptor Ligand B06
A Bagán, JA Morales-García, C Griñán-Ferré… - International journal of …, 2022 - mdpi.com
The impact of neurodegenerative diseases (ND) is becoming unbearable for humankind
due to their vast prevalence and the lack of efficacious treatments. In this scenario, we …
due to their vast prevalence and the lack of efficacious treatments. In this scenario, we …
Određivanje strukture farmakofore, dizajn i in vitro ispitivanje liganada sa višestrukim dejstvom kao potencijalno efikasnijih terapeutika složenih neuroloških i …
M Radan - Универзитет у Београду, 2022 - nardus.mpn.gov.rs
Disfunkcija serotoninske i dopaminske neurotransmisije u mozgu je u osnovi patofiziologije
brojnih neuroloških i mentalnih oboljenja. Definisanje protokola koji integriše in silico i in …
brojnih neuroloških i mentalnih oboljenja. Definisanje protokola koji integriše in silico i in …
Insights into the Pharmacokinetics and In Vitro Cell-Based Studies of the Imidazoline I2 Receptor Ligand B06
A Bagan Polonio, JA Morales-García… - International Journal of …, 2022 - diposit.ub.edu
The impact of neurodegenerative diseases (ND) is becoming unbearable for humankind
due to their vast prevalence and the lack of efficacious treatments. In this scenario, we …
due to their vast prevalence and the lack of efficacious treatments. In this scenario, we …
[PDF][PDF] TESIS DOCTORAL Modulación de la sinapsis y su papel en patologías del sistema nervioso
AS Madera - 2022 - docta.ucm.es
Las sinaptopatías son aquellas enfermedades del sistema nervioso que se producen como
consecuencia de un desequilibrio en el funcionamiento normal de las sinapsis. Estas …
consecuencia de un desequilibrio en el funcionamiento normal de las sinapsis. Estas …