Comparative toxicogenomics of glyphosate and roundup herbicides by mammalian stem cell-based genotoxicity assays and molecular profiling in sprague-dawley …
R Mesnage, M Ibragim, D Mandrioli… - Toxicological …, 2022 - academic.oup.com
Whether glyphosate-based herbicides (GBHs) are more potent than glyphosate alone at
activating cellular mechanisms, which drive carcinogenesis remain controversial. As GBHs …
activating cellular mechanisms, which drive carcinogenesis remain controversial. As GBHs …
A multiple-testing procedure for high-dimensional mediation hypotheses
JY Dai, JL Stanford, M LeBlanc - Journal of the American Statistical …, 2022 - Taylor & Francis
Mediation analysis is of rising interest in epidemiologic studies and clinical trials. Among
existing methods, the joint significance test yields an overly conservative Type I error rate …
existing methods, the joint significance test yields an overly conservative Type I error rate …
[HTML][HTML] Machine learning-based genome-wide salivary DNA methylation analysis for identification of noninvasive biomarkers in oral cancer diagnosis
Simple Summary Because tissue biopsy is the gold standard for diagnosing oral cancer, it is
often performed to confirm disease during screening, management, and monitoring …
often performed to confirm disease during screening, management, and monitoring …
[HTML][HTML] DNA methylation profiles in the blood of newborn term infants born to mothers with obesity
A Sasaki, KE Murphy, L Briollais, PO McGowan… - PLoS …, 2022 - journals.plos.org
Maternal obesity is an important risk factor for childhood obesity and influences the
prevalence of metabolic diseases in offspring. As childhood obesity is influenced by …
prevalence of metabolic diseases in offspring. As childhood obesity is influenced by …
[HTML][HTML] Differential methylation patterns in lean and obese non-alcoholic steatohepatitis-associated hepatocellular carcinoma
Background Nonalcoholic fatty liver disease affects about 24% of the world's population and
may progress to nonalcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular …
may progress to nonalcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular …
Comparison and imputation-aided integration of five commercial platforms for targeted DNA methylome analysis
Targeted bisulfite sequencing (TBS) has become the method of choice for the cost-effective,
targeted analysis of the human methylome at base-pair resolution. In this study, we …
targeted analysis of the human methylome at base-pair resolution. In this study, we …
[HTML][HTML] Differential DNA methylation in Pacific oyster reproductive tissue in response to ocean acidification
YR Venkataraman, SJ White, SB Roberts - BMC genomics, 2022 - Springer
Background There is a need to investigate mechanisms of phenotypic plasticity in marine
invertebrates as negative effects of climate change, like ocean acidification, are experienced …
invertebrates as negative effects of climate change, like ocean acidification, are experienced …
[HTML][HTML] Integrative analysis of multi-omics data to detect the underlying molecular mechanisms for obesity in vivo in humans
Background Obesity is a complex, multifactorial condition in which genetic play an important
role. Most of the systematic studies currently focuses on individual omics aspect and provide …
role. Most of the systematic studies currently focuses on individual omics aspect and provide …
[HTML][HTML] Circulating tumor cell methylation profiles reveal the classification and evolution of non-small cell lung cancer
JH Jiang, J Gao, CY Chen, YQ Ao, J Li… - Translational Lung …, 2022 - ncbi.nlm.nih.gov
Background The ability of circulating tumor cells (CTCs) to identify lung adenocarcinoma
(LUAD) and lung squamous cell carcinoma (LUSC) could improve pathological diagnosis …
(LUAD) and lung squamous cell carcinoma (LUSC) could improve pathological diagnosis …
In vitro-and in vivo-produced male dairy calves show molecular differences in the hepatic and muscular energy regulation
MB Rabaglino, JBM Secher, P Hyttel… - Biology of …, 2022 - academic.oup.com
In cattle, the in vitro production (IVP) of embryos is becoming more relevant than embryos
produced in vivo, ie after multiple ovulation and embryo transfer (MOET). However, the …
produced in vivo, ie after multiple ovulation and embryo transfer (MOET). However, the …