Comparative toxicogenomics of glyphosate and roundup herbicides by mammalian stem cell-based genotoxicity assays and molecular profiling in sprague-dawley …

R Mesnage, M Ibragim, D Mandrioli… - Toxicological …, 2022 - academic.oup.com
Whether glyphosate-based herbicides (GBHs) are more potent than glyphosate alone at
activating cellular mechanisms, which drive carcinogenesis remain controversial. As GBHs …

A multiple-testing procedure for high-dimensional mediation hypotheses

JY Dai, JL Stanford, M LeBlanc - Journal of the American Statistical …, 2022 - Taylor & Francis
Mediation analysis is of rising interest in epidemiologic studies and clinical trials. Among
existing methods, the joint significance test yields an overly conservative Type I error rate …

[HTML][HTML] Machine learning-based genome-wide salivary DNA methylation analysis for identification of noninvasive biomarkers in oral cancer diagnosis

J Adeoye, CCJ Wan, LW Zheng, P Thomson, SW Choi… - Cancers, 2022 - mdpi.com
Simple Summary Because tissue biopsy is the gold standard for diagnosing oral cancer, it is
often performed to confirm disease during screening, management, and monitoring …

[HTML][HTML] DNA methylation profiles in the blood of newborn term infants born to mothers with obesity

A Sasaki, KE Murphy, L Briollais, PO McGowan… - PLoS …, 2022 - journals.plos.org
Maternal obesity is an important risk factor for childhood obesity and influences the
prevalence of metabolic diseases in offspring. As childhood obesity is influenced by …

[HTML][HTML] Differential methylation patterns in lean and obese non-alcoholic steatohepatitis-associated hepatocellular carcinoma

E Hymel, KW Fisher, PA Farazi - BMC cancer, 2022 - Springer
Background Nonalcoholic fatty liver disease affects about 24% of the world's population and
may progress to nonalcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular …

Comparison and imputation-aided integration of five commercial platforms for targeted DNA methylome analysis

M Tanić, I Moghul, S Rodney, P Dhami… - Nature …, 2022 - nature.com
Targeted bisulfite sequencing (TBS) has become the method of choice for the cost-effective,
targeted analysis of the human methylome at base-pair resolution. In this study, we …

[HTML][HTML] Differential DNA methylation in Pacific oyster reproductive tissue in response to ocean acidification

YR Venkataraman, SJ White, SB Roberts - BMC genomics, 2022 - Springer
Background There is a need to investigate mechanisms of phenotypic plasticity in marine
invertebrates as negative effects of climate change, like ocean acidification, are experienced …

[HTML][HTML] Integrative analysis of multi-omics data to detect the underlying molecular mechanisms for obesity in vivo in humans

Q Zhang, XH Meng, C Qiu, H Shen, Q Zhao, LJ Zhao… - Human Genomics, 2022 - Springer
Background Obesity is a complex, multifactorial condition in which genetic play an important
role. Most of the systematic studies currently focuses on individual omics aspect and provide …

[HTML][HTML] Circulating tumor cell methylation profiles reveal the classification and evolution of non-small cell lung cancer

JH Jiang, J Gao, CY Chen, YQ Ao, J Li… - Translational Lung …, 2022 - ncbi.nlm.nih.gov
Background The ability of circulating tumor cells (CTCs) to identify lung adenocarcinoma
(LUAD) and lung squamous cell carcinoma (LUSC) could improve pathological diagnosis …

In vitro-and in vivo-produced male dairy calves show molecular differences in the hepatic and muscular energy regulation

MB Rabaglino, JBM Secher, P Hyttel… - Biology of …, 2022 - academic.oup.com
In cattle, the in vitro production (IVP) of embryos is becoming more relevant than embryos
produced in vivo, ie after multiple ovulation and embryo transfer (MOET). However, the …