Background: The connection between uric acid (UA) and renal impairment is well known
due to the urate capacity to precipitate within the tubules or extra-renal system. Emerging …

Cellular senescence is an irreversible state of cell cycle arrest occurring in response to
stressful stimuli, such as telomere attrition, DNA damage, reactive oxygen species, and …

Caffeine is the most frequently used substance with a central nervous system stimulant
effect, but its consumption is most often due to the intake of foods and drinks that contain it …

Mitochondrial function, including oxidative phosphorylation (OXPHOS), mitochondrial
biogenesis, and mitochondria dynamics, are essential for the maintenance of renal health …

Oxidative stress arises when the generation of reactive oxygen species or reactive nitrogen
species overwhelms antioxidant systems. Developing kidneys are vulnerable to oxidative …

Background and Objectives: Hyperuricemia and liver steatosis are risk factors for
cardiovascular diseases and mortality. The use of natural compounds could be a safe and …

Heavy metals, including cadmium, are suspected to increase serum uric acid levels and
hyperuricemia in both gender, but the evidences about this are inconclusive. To determine …

Hyperuricemia was associated with the overproduction or inadequate excretion of uric acid,
while its association with gut microbiota has emerged although few studies were focused on …

Background Uric acid (UA) has anti-and pro-inflammatory properties. We previously
revealed that elevated serum UA levels provide protection against murine small intestinal …

Hyperuricemia (HUA) refers to a physiological condition of high serum uric acid (SUA) level
in the body, which may cause an increased risk of several chronic diseases. The kidney's …