NKG2D discriminates diverse ligands through selectively mechano‐regulated ligand conformational changes

J Fan, J Shi, Y Zhang, J Liu, C An, H Zhu, P Wu… - The EMBO …, 2022 - embopress.org
Stimulatory immune receptor NKG2D binds diverse ligands to elicit differential anti‐tumor
and anti‐virus immune responses. Two conflicting degeneracy recognition models based on …

Spatially resolved in silico modeling of NKG2D signaling kinetics suggests a key role of NKG2D and Vav1 Co-clustering in generating natural killer cell activation

RK Grewal, J Das - PLOS Computational Biology, 2022 - journals.plos.org
Natural Killer (NK) cells provide key resistance against viral infections and tumors. A diverse
set of activating and inhibitory NK cell receptors (NKRs) interact with cognate ligands …