Sarco/Endoplasmic Reticulum Ca2+ ATPase 2 Activator Ameliorates Endothelial Dysfunction; Insulin Resistance in Diabetic Mice
T Kimura, K Kagami, A Sato, A Osaki, K Ito, S Horii… - Cells, 2022 - mdpi.com
Background: Sarco/endoplasmic reticulum Ca2+-ATPase2 (SERCA2) is impaired in various
organs in animal models of diabetes. The purpose of this study was to test the effects of an …
organs in animal models of diabetes. The purpose of this study was to test the effects of an …
Substitution of SERCA2 Cys674 aggravates cardiac fibrosis by promoting the transformation of cardiac fibroblasts to cardiac myofibroblasts
X Huang, X Lin, L Wang, Y Xie, Y Que, S Li, P Hu… - Biochemical …, 2022 - Elsevier
Abstract Sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase 2 (SERCA2) is vital to maintain
intracellular calcium homeostasis, and its redox Cys 674 (C674) is the key to regulating …
intracellular calcium homeostasis, and its redox Cys 674 (C674) is the key to regulating …
Role of airway smooth muscle cell phenotypes in airway tone and obstruction in guinea pig asthma model
MD Álvarez-Santos, M Álvarez-González… - Allergy, Asthma & …, 2022 - Springer
Background Airway obstruction (AO) in asthma is driven by airway smooth muscle (ASM)
contraction. AO can be induced extrinsically by direct stimulation of ASM with contractile …
contraction. AO can be induced extrinsically by direct stimulation of ASM with contractile …
Substitution of SERCA2 Cys674 accelerates aortic aneurysm by inducing endoplasmic reticulum stress and promoting cell apoptosis
L Wang, Z Yang, S Wang, Y Que, X Shu… - British Journal of …, 2022 - Wiley Online Library
Background and Purpose The Cys674 residue (C674) in the sarcoplasmic/endoplasmic
reticulum Ca2+ ATPase 2 (SERCA2) is key to maintaining its enzyme activity. The …
reticulum Ca2+ ATPase 2 (SERCA2) is key to maintaining its enzyme activity. The …
[HTML][HTML] The substitution of SERCA2 redox cysteine 674 promotes pulmonary vascular remodeling by activating IRE1α/XBP1s pathway
W Yu, G Xu, H Chen, L Xiao, G Liu, P Hu, S Li… - … Pharmaceutica Sinica B, 2022 - Elsevier
Pulmonary hypertension (PH) is a life-threatening disease characterized by pulmonary
vascular remodeling, in which hyperproliferation of pulmonary artery smooth muscle cells …
vascular remodeling, in which hyperproliferation of pulmonary artery smooth muscle cells …
Hypoxia damages endothelial cell angiogenic function by reducing the Ca2+ restoring ability of the endoplasmic reticulum
K Yan, B Song, Y Zhen - Biochemical and Biophysical Research …, 2022 - Elsevier
The angiogenic function of endothelial cells (ECs) is very important to tissues and organs
that suffer from hypoxic injury. Exploring the role of endoplasmic reticulum (ER) Ca 2+ …
that suffer from hypoxic injury. Exploring the role of endoplasmic reticulum (ER) Ca 2+ …
Downhill running induced DNA damage enhances mitochondrial membrane permeability by facilitating ER-mitochondria signaling
J Li, B Zhao, S Chen, Z Wang, K Shi, B Lei… - Journal of Muscle …, 2022 - Springer
To observe whether downhill running can lead to DNA damage in skeletal muscle cells and
changes in mitochondrial membrane permeability and to explore whether the DNA damage …
changes in mitochondrial membrane permeability and to explore whether the DNA damage …
Substitution of the SERCA2 Cys674 reactive thiol accelerates atherosclerosis by inducing endoplasmic reticulum stress and inflammation
H Su, Y Mei, S Luo, H Wu, Y He… - British Journal of …, 2022 - Wiley Online Library
Background and Purpose The cysteine674 (C674) thiol of sarcoplasmic/endoplasmic
reticulum Ca2+ ATPase 2 is easily and irreversibly oxidized under atherosclerotic …
reticulum Ca2+ ATPase 2 is easily and irreversibly oxidized under atherosclerotic …