Primary myelofibrosis (PMF) is one of three myeloproliferative neoplasms (MPN) that are
morphologically and molecularly inter-related, the other two being polycythemia vera (PV) …

Megakaryocytes (MKs) are typical cellular components in the circulating blood flowing from
the heart into the lungs. Physiologically, MKs function as an important regulator of platelet …

G6b-B is a megakaryocyte lineage-specific immunoreceptor tyrosine-based inhibition motif–
containing receptor, essential for platelet homeostasis. Mice with a genomic deletion of the …

Intrauterine adhesion (IUA) is an endometrial fibrotic disease with unclear pathogenesis.
Increasing evidence suggested the important role of competitive endogenous RNA (ceRNA) …

Myelofibrosis (MF) is a BCR-ABL1–negative myeloproliferative neoplasm characterized by
anemia, extramedullary hematopoiesis, bone marrow fibrosis, splenomegaly, constitutional …

Acute megakaryoblastic leukaemia (AMKL) is characterized by expansion of
megakaryoblasts, which are hyper-proliferative cells that fail to undergo differentiation …

Myelofibrosis (MF) is a haematopoietic stem cell tumour caused by the lack of BCR-ABL
translocation due to point mutations in Janus kinases (JAKs). In previous years, dealing with …

Pigment epithelial-derived factor (PEDF) exerts a broad spectrum of activities and has been
implicated in diverse biological processes and a variety of diseases. However, the role of …

阻断PAK1激酶活性对急性巨核细胞白血病细胞分化及凋亡的影响- PMC Back to Top Skip to
main content NIH NLM Logo Access keys NCBI Homepage MyNCBI Homepage Main Content …

Given its rarity, multi-faceted clinical presentation and the relative paucity of approved
therapies, the management of myeloproliferative neoplasm (MPN)-associated myelofibrosis …