Major recent advances and previous data have led to a plausible model of how key proteins
mediate neurotransmitter release. In this model, the soluble N-ethylmaleimide-sensitive …

Intracellular vesicle trafficking is the fundamental process to maintain the homeostasis of
membrane-enclosed organelles in eukaryotic cells. These organelles transport cargo from …

Axons in the adult mammalian central nervous system fail to regenerate after spinal cord
injury. Neurons lose their capacity to regenerate during development, but the intracellular …

Within 1 millisecond of action potential arrival at presynaptic terminals voltage–gated Ca2+
channels open. The Ca2+ channels are linked to synaptic vesicles which are tethered by …

The nervous system is important, because it regulates the physiological function of the body.
Neurons are the most basic structural and functional unit of the nervous system. The …

The mechanism of neurotransmitter release has been extensively characterized, showing
that vesicle fusion is mediated by the SNARE complex formed by syntaxin‐1, SNAP‐25 and …

Despite its evident importance to learning theory and models, the manner in which the
lateral perforant path (LPP) transforms signals from entorhinal cortex to hippocampus is not …

Paramagnetic NMR constraints are very useful to study protein interdomain motion, but their
interpretation is not always straightforward. On the example of the particularly flexible …

Munc13 proteins are priming factors for SNARE-dependent exocytosis, which are activated
by diacylglycerol (DAG)-binding to their C1-domain. Several Munc13 paralogs exist, but …

Neurotransmitters are released by exocytosis from synaptic vesicles at the active zone in the
presynaptic terminal. The scaffold of the active zone consists of only a few evolutionarily …