[HTML][HTML] Guidelines for bioinformatics of single-cell sequencing data analysis in Alzheimer's disease: review, recommendation, implementation and application
Alzheimer's disease (AD) is the most common form of dementia, characterized by
progressive cognitive impairment and neurodegeneration. Extensive clinical and genomic …
progressive cognitive impairment and neurodegeneration. Extensive clinical and genomic …
[HTML][HTML] Decoding the human face: progress and challenges in understanding the genetics of craniofacial morphology
Variations in the form of the human face, which plays a role in our individual identities and
societal interactions, have fascinated scientists and artists alike. Here, we review our current …
societal interactions, have fascinated scientists and artists alike. Here, we review our current …
Single-nucleus cross-tissue molecular reference maps toward understanding disease gene function
Understanding gene function and regulation in homeostasis and disease requires
knowledge of the cellular and tissue contexts in which genes are expressed. Here, we …
knowledge of the cellular and tissue contexts in which genes are expressed. Here, we …
Single-cell eQTL models reveal dynamic T cell state dependence of disease loci
Non-coding genetic variants may cause disease by modulating gene expression. However,
identifying these expression quantitative trait loci (eQTLs) is complicated by differences in …
identifying these expression quantitative trait loci (eQTLs) is complicated by differences in …
[HTML][HTML] Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation
B Soskic, E Cano-Gamez, DJ Smyth, K Ambridge… - Nature …, 2022 - nature.com
During activation, T cells undergo extensive gene expression changes that shape the
properties of cells to exert their effector function. Understanding the regulation of this …
properties of cells to exert their effector function. Understanding the regulation of this …
[HTML][HTML] Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals widespread, context-specific gene expression regulation upon pathogenic …
The host's gene expression and gene regulatory response to pathogen exposure can be
influenced by a combination of the host's genetic background, the type of and exposure time …
influenced by a combination of the host's genetic background, the type of and exposure time …
The missing link between genetic association and regulatory function
The genetic basis of most traits is highly polygenic and dominated by non-coding alleles. It is
widely assumed that such alleles exert small regulatory effects on the expression of cis …
widely assumed that such alleles exert small regulatory effects on the expression of cis …
[HTML][HTML] Gastruloids: Pluripotent stem cell models of mammalian gastrulation and embryo engineering
Gastrulation is a fundamental and critical process of animal development whereby the mass
of cells that results from the proliferation of the zygote transforms itself into a recognizable …
of cells that results from the proliferation of the zygote transforms itself into a recognizable …
[HTML][HTML] Single-cell and single-nuclei RNA sequencing as powerful tools to decipher cellular heterogeneity and dysregulation in neurodegenerative diseases
R Cuevas-Diaz Duran, JC González-Orozco… - Frontiers in Cell and …, 2022 - frontiersin.org
Neurodegenerative diseases affect millions of people worldwide and there are currently no
cures. Two types of common neurodegenerative diseases are Alzheimer's (AD) and …
cures. Two types of common neurodegenerative diseases are Alzheimer's (AD) and …
[HTML][HTML] Single-cell sequencing reveals lineage-specific dynamic genetic regulation of gene expression during human cardiomyocyte differentiation
Dynamic and temporally specific gene regulatory changes may underlie unexplained
genetic associations with complex disease. During a dynamic process such as cellular …
genetic associations with complex disease. During a dynamic process such as cellular …