Age-related macular degeneration (AMD) is a complex eye disorder and is the leading
cause of incurable blindness worldwide in the elderly. Clinically, AMD initially affects the …

Diabetic neuropathy, also called peripheral diabetic neuropathy (PDN), is among the most
significant diabetes health consequences, alongside diabetic nephropathy, diabetic …

It is now well understood that the bone marrow (BM) compartment can sense systemic
inflammatory signals and adapt through increased proliferation and lineage skewing. These …

The purpose of this study is to explore the effect and mechanism of neuritin overexpression
in the bone marrow on peripheral neuropathy in type 2 diabetic (db/db) mice. We analyzed …

Circadian clocks are cell-autonomous, molecular pacemakers regulating a wide variety of
behavioural and physiological processes in accordance with the 24​ h light/dark cycle. The …

Abstract 2020 marked the 20th anniversary of the discovery of the angiotensin-converting
enzyme 2 (ACE2). This major event that changed the way we see the renin–angiotensin …

Impairment of bone marrow‐derived hematopoietic stem/progenitor cells (HSPCs)
contributes to the progression of vascular complications in subjects with diabetes. Very small …

Diabetes mellitus has multiple negative effects on regenerative processes, especially on
wound and fracture healing. Despite the well-known negative effects of diabetes on the …

Pigment epithelium-derived factor (PEDF), an endogenous Wnt signaling inhibitor in the
serine proteinase inhibitors (SERPIN) super family, is present in multiple organs, including …

Age-related macular degeneration (AMD) is degenerative retinal eye disease that affects
central vision. It is estimated that by 2040, approximately 288 million people in the world …