Chronic pain is a maladaptive condition affecting 7%− 10% of the population worldwide and
can be accompanied by depression, anxiety, and insomnia. In particular, chronic pain is …

A metabolic illness known as non-alcoholic fatty liver disease (NAFLD), affects more than
one-quarter of the world's population. Bile acids (BAs), as detergents involved in lipid …

Background The noradrenergic neurons of locus coeruleus (LC) project to the spinal dorsal
horn (SDH), and release norepinephrine (NE) to inhibit pain transmission. However, its …

Central post-stroke pain (CPSP) and associated depression remain poorly understood and
pharmacological treatments are unsatisfactory. Recently, microglia activation was suggested …

Diabetic neuropathic pain (DNP) is a diabetes complication experienced by many patients.
Ventrolateral periaqueductal gray (vlPAG) neurons are essential mediators of the …

Astrocytes, the most abundant glial cells in the mammalian brain, directly associate with and
regulate neuronal processes and synapses and are important regulators of brain …

Around 20% of the American population have chronic pain and estimates in other Western
countries report similar numbers. This represents a major challenge for global health care …

Neuropathic pain, whose symptoms are characterized by spontaneous and irritation-
induced painful sensations, is a condition that poses a global burden. Numerous …

Hepatic encephalopathy describes an array of neurological complications that arise due to
liver insufficiency. The pathogenesis of hepatic encephalopathy shares a longstanding …

Objective The purpose of our bibliometric analysis was to explore the disciplinary hotspots
and collaborative networks in research on neuropathic pain (NPP) during in the past 20 …