Women live longer than men but experience greater disability and a longer period of illness
as they age. Despite clear sex differences in aging, the impact of pregnancy and its …

The advancement of human genomics has revolutionized our understanding of the genetic
architecture of many skeletal diseases, including osteoporosis. However, interpreting results …

Topological network alignment aims to align two networks node-wise in order to maximize
the observed common connection (edge) topology between them. The topological alignment …

The pancreas is a central organ for human diseases. Most alleles uncovered by genome-
wide association studies of pancreatic dysfunction traits overlap with non-coding sequences …

The receptor tyrosine kinase Ret plays a critical role in regulating enteric nervous system
(ENS) development. Ret is important for proliferation, migration, and survival of enteric …

Many key signaling molecules used to build tissues during embryonic development are re-
activated at injury sites to stimulate tissue regeneration and repair. Bone morphogenetic …

Troponin I type 1b (Tnni1b) is thought to be a novel isoform that is expressed only in the
zebrafish heart. Knocking down of tnni1b can lead to cardiac defects in zebrafish. Although …

Background Synovial joints form in several steps, starting with the formation of an interzone,
a condensation of mesenchymal cells at the sites of prospective joints. Despite the …

Transcription factors bind to their target DNA sites in a sequence-specific manner,
modulating gene expression, and playing important roles in development, body patterning …

Disruption of the human short stature homeobox (SHOX) gene causes shortening of the
middle limb segment (zeugopod), affecting up to 1: 1000 individuals. SHOX deficiencies are …