Cancer is a disease of uncontrollably reproducing cells. It is governed by biochemical
pathways that have escaped the regulatory bounds of normal homeostatic balance. This …

Biomolecular condensates organize cellular functions in the absence of membranes. These
membraneless organelles can form through liquid–liquid phase separation coalescing RNA …

Modern drug delivery technology began in 1952 with the advent of the Spansule® sustained-
release capsule technology, which can deliver a drug for 12 h after oral administration …

Lipid nanoparticles (LNPs) are the leading nonviral technologies for the delivery of
exogenous RNA to target cells in vivo. As systemic delivery platforms, these technologies …

Lysine-specific demethylase 6A (KDM6A), also named UTX, is frequently mutated in bladder
cancer (BCa). Although known as a tumor suppressor, KDM6A's therapeutic potential in the …

The RIG‐I pathway can be activated by RNA containing 5′ triphosphate, leading to type I
interferon release and immune activation. Hence, RIG‐I agonists have been used to induce …

Microfluidics is an emerging technology that can be employed as a powerful tool for
designing lipid nano-microsized structures for biological applications. Those lipid structures …

RNA-binding proteins (RBPs) are of fundamental importance for post-transcriptional gene
regulation and protein synthesis. They are required for pre-mRNA processing and for RNA …

RNAi (RNA interference)-based technology is emerging as a versatile tool which has been
widely utilized in the treatment of various diseases. siRNA can alter gene expression by …

Although mesenchymal stromal (stem) cell (MSC) administration attenuates sepsis-induced
lung injury in pre-clinical models, the mechanism (s) of action and host immune system …