Deconstructing a syndrome: genomic insights into PCOS causal mechanisms and classification

M Dapas, A Dunaif - Endocrine reviews, 2022 - academic.oup.com
Polycystic ovary syndrome (PCOS) is among the most common disorders in women of
reproductive age, affecting up to 15% worldwide, depending on the diagnostic criteria …

[HTML][HTML] Polycystic ovary syndrome: an evolutionary adaptation to lifestyle and the environment

J Parker, C O'brien, J Hawrelak, FL Gersh - International journal of …, 2022 - mdpi.com
Polycystic ovary syndrome (PCOS) is increasingly recognized as a complex metabolic
disorder that manifests in genetically susceptible women following a range of negative …

[HTML][HTML] Obesity and risk of female reproductive conditions: A Mendelian randomisation study

SS Venkatesh, T Ferreira, S Benonisdottir… - PLoS …, 2022 - journals.plos.org
Background Obesity is observationally associated with altered risk of many female
reproductive conditions. These include polycystic ovary syndrome (PCOS), abnormal uterine …

Causes and consequences of polycystic ovary syndrome: insights from Mendelian randomization

T Zhu, MO Goodarzi - The Journal of Clinical Endocrinology & …, 2022 - academic.oup.com
Context Although polycystic ovary syndrome (PCOS) is the most common endocrinopathy
affecting women of reproductive age, risk factors that may cause the syndrome are poorly …

[HTML][HTML] Polycystic ovary syndrome: a “risk-enhancing” factor for cardiovascular disease

C Guan, S Zahid, AS Minhas, P Ouyang, A Vaught… - Fertility and sterility, 2022 - Elsevier
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women
of reproductive age and is hallmarked by hyperandrogenism, oligo-ovulation, and polycystic …

[PDF][PDF] A multi-level investigation of the genetic relationship between endometriosis and ovarian cancer histotypes

S Mortlock, RI Corona, PF Kho, P Pharoah, JH Seo… - Cell Reports …, 2022 - cell.com
Endometriosis is associated with increased risk of epithelial ovarian cancers (EOCs). Using
data from large endometriosis and EOC genome-wide association meta-analyses, we …

Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation

S Martin, J Tyrrell, EL Thomas, MJ Bown, AR Wood… - Elife, 2022 - elifesciences.org
Background: Some individuals living with obesity may be relatively metabolically healthy,
whilst others suffer from multiple conditions that may be linked to adverse metabolic effects …

[HTML][HTML] Criteria for diagnosis of polycystic ovary syndrome during adolescence: literature review

AS Peña, E Codner, S Witchel - Diagnostics, 2022 - mdpi.com
Polycystic ovary syndrome (PCOS) is one of the most common endocrine conditions in
women. PCOS may be more challenging to diagnose during adolescence due to an overlap …

[HTML][HTML] Why are women with polycystic ovary syndrome obese?

TM Barber - British Medical Bulletin, 2022 - ncbi.nlm.nih.gov
Introduction: Polycystic ovary syndrome (PCOS) is a common condition characterized by
reproductive, hyperandrogenic and dysmetabolic features, and often becomes clinically …

[HTML][HTML] Sex hormone candidate gene polymorphisms are associated with endometriosis

I Golovchenko, B Aizikovich, O Golovchenko… - International Journal of …, 2022 - mdpi.com
The present study was designed to examine whether sex hormone polymorphisms proven
by GWAS are associated with endometriosis risk. Unrelated female participants totaling …