Potential synthetic lethality for breast cancer: A selective sirtuin 2 inhibitor combined with a multiple kinase inhibitor sorafenib
Sorafenib is a clinically useful multiple kinase inhibitor for the treatment of kidney cancer,
liver cancer and acute myelocytic leukemia, while it has shown weak efficacy in suppressing …
liver cancer and acute myelocytic leukemia, while it has shown weak efficacy in suppressing …
4-Aminopyrazolopyrimidine scaffold and its deformation in the design of tyrosine and serine/threonine kinase inhibitors in medicinal chemistry
X Chen, Y Huang, W Xu, Y Cai, Y Yang - RSC Medicinal Chemistry, 2022 - pubs.rsc.org
The 4-Aminopyrazolopyrimidine scaffold has been an interesting pharmacophore since the
disclosure of the intimate connection between small-molecule inhibitors and the treatment of …
disclosure of the intimate connection between small-molecule inhibitors and the treatment of …
Tyrosine kinase SRC-mediated YAP1-KLF5 module regulates cancer stemness and metastasis in TNBC
H Zou, J Luo, Y Guo, P Li - 2022 - researchsquare.com
SRC was the first identified oncogene, and its aberrant activation has been implicated as a
driving event in tumor initiation and progression. However, its role in cancer stemness …
driving event in tumor initiation and progression. However, its role in cancer stemness …