Emerging evidence suggests that mitochondrial dysfunction mediates the pathogenesis for
non-alcoholic fatty liver disease (NAFLD). Hydroxytyrosol (HT) is a key component of extra …

A bio-responsive nanoparticle was formed by the directed self-assembly (DSA) of a
hydrophobic NIR-fluorophore with poloxamer P188. Fluorophore emission was switched off …

Fluorescence microscopy is a key tool in the biological sciences, which finds use as a
routine laboratory technique (eg, epifluorescence microscope) or more advanced confocal …

Duchenne muscular dystrophy (DMD) is a fatal muscle-wasting disorder caused by
mutations in the Dystrophin gene and for which there is currently no cure. To bridge the gap …

Autophagy activation has the potential to ameliorate neurodegenerative disease
phenotypes, including protein aggregation, lipid level perturbations and axonal trafficking …

Ubiquitin C-terminal hydrolase L1 (UCHL1) is a deubiquitinating enzyme that was originally
found in neurons. We found that UCHL1 is highly expressed in slow oxidative skeletal …

For long-term live-cell fluorescence imaging and biosensing, it is crucial to work with a dye
that has high fluorescence quantum yield and photostability without being detrimental to the …

Targeting of fluorescent sensors is generally achieved by attachment of a targeting group to
the sensor via a linker. This chapter provides an overview of the current targeting strategies …

Skeletal muscle lipid infiltration, known as myosteatosis, increases with obesity and ageing.
Myosteatosis has also recently been discovered as a negative prognostic factor for several …

This last Editorial for 2022 begins with presentation of the “Most popular articles published in
HCB in 2020.” We then follow with highlights from two Original Articles investigating the …