The field of genomics has benefited greatly from its “openness” approach to data sharing.
However, with the increasing volume of sequence information being created and stored and …

Precision medicine programs to identify clinically relevant genetic variation have been
revolutionized by access to increasingly affordable high-throughput sequencing (HTS) …

Genome-wide sequencing (GWS) is a standard of care for diagnosis of suspected genetic
disorders, but the proportion of patients found to have pathogenic or likely pathogenic …

Indigenous peoples are under-represented in genomic datasets, which can lead to limited
accuracy and utility of machine learning models in precision health. While open data sharing …

Research teams developing biobanks and/or genomic databases must develop policies for
the disclosure and reporting of potentially actionable genomic results to research …

Background The decreasing cost of DNA sequencing has led to a great increase in our
knowledge about genetic variation. While population-scale projects bring important insight …

This paper explores the manners in which Indigenous and allied non-Indigenous
researchers, medical directors, and knowledge-keepers (among others) extend the ethical …

The underrepresentation of non-European ancestry groups in current genomic databases
complicates interpretation of their genetic test results, yielding a much higher prevalence of …

Indigenous people from the American continent, or Native Americans, are underrepresented
in the collective genomic knowledge. A minimal percentage of individuals in international …

AIM: Posthumous electronic healthcare data (PHCD) are ubiquitous and increasing in
volume. Despite their potential utility and value, no empirically-derived, publicly-generated …