3D spatial genome organization in the nervous system: From development and plasticity to disease
Chromatin is organized into multiscale three-dimensional structures, including chromosome
territories, A/B compartments, topologically associating domains, and chromatin loops. This …
territories, A/B compartments, topologically associating domains, and chromatin loops. This …
Genetics of the human microglia regulome refines Alzheimer's disease risk loci
Microglia are brain myeloid cells that play a critical role in neuroimmunity and the etiology of
Alzheimer's disease (AD), yet our understanding of how the genetic regulatory landscape …
Alzheimer's disease (AD), yet our understanding of how the genetic regulatory landscape …
Chromatin domain alterations linked to 3D genome organization in a large cohort of schizophrenia and bipolar disorder brains
Chromosomal organization, scaling from the 147-base pair (bp) nucleosome to megabase-
ranging domains encompassing multiple transcriptional units, including heritability loci for …
ranging domains encompassing multiple transcriptional units, including heritability loci for …
Genetic variation in correlated regulatory region of Immunity
Studying the interplay between genetic variation, epigenetic changes and regulation of gene
expression in immune cells is important to understand the modification of cellular states in …
expression in immune cells is important to understand the modification of cellular states in …
[PDF][PDF] Multi-omic profiling of the developing human cerebral cortex at the single cell level
KJ Li, D Lee, GC Yuan, JF Fullard - academia.edu
The cellular complexity of the human brain is established via dynamic changes in gene
expression throughout development that is mediated, in part, by the spatiotemporal activity …
expression throughout development that is mediated, in part, by the spatiotemporal activity …