Insulin fibrillation: Strategies for inhibition
M Qafary, F Rashno, K Khajeh, M Khaledi… - Progress in Biophysics …, 2022 - Elsevier
Insulin and its homologous are the most utilized protein drugs due to their role in diabetic
patients' treatment. Insulin forms amyloid-like fibrils in vivo at the injection site. Therefore, the …
patients' treatment. Insulin forms amyloid-like fibrils in vivo at the injection site. Therefore, the …
Polyisobutylene-based glycopolymers as potent inhibitors for in vitro insulin aggregation
A family of amphiphilic diblock copolymers containing a hydrophobic polyisobutylene (PIB,
Mn= 1000 g mol− 1) segment and a hydrophilic block with sugar pendants has been …
Mn= 1000 g mol− 1) segment and a hydrophilic block with sugar pendants has been …
Dietary anthocyanins inhibit insulin fibril formation and cytotoxicity in 3T3-L1 preadipocytes
P Channuwong, K Salae, S Chongruchiroj… - International Journal of …, 2022 - Elsevier
Insulin fibril formation decreases the effectiveness of insulin therapy and causes amyloidosis
in diabetes. Studies suggest that phytochemicals are capable of inhibiting fibril formation …
in diabetes. Studies suggest that phytochemicals are capable of inhibiting fibril formation …
Silibinin Protects against H2O2-Induced Oxidative Damage in SH-SY5Y Cells by Improving Mitochondrial Function
F Tie, Y Fu, N Hu, H Wang - Antioxidants, 2022 - mdpi.com
Oxidative stress plays a critical role in the pathogenesis of various neurodegenerative
diseases. Increasing evidence suggests the association of mitochondrial abnormalities with …
diseases. Increasing evidence suggests the association of mitochondrial abnormalities with …
Pomegranate seed polyphenol-based nanosheets as an efficient inhibitor of amyloid fibril assembly and cytotoxicity of HEWL
Poor water solubility and low bioavailability are considered as two main factors restricting
therapeutic applications of natural polyphenols in relation to various disorders including …
therapeutic applications of natural polyphenols in relation to various disorders including …
Experimental and theoretical studies on the anti‐amyloidogenic and destabilizing effects of pyrogallol against human insulin protein
P Shouhani, S Bahramikia… - Journal of Food …, 2022 - Wiley Online Library
One of the major problems caused by repeated subcutaneous insulin injections in patients
with diabetes is insulin amyloidosis. Understanding the molecular mechanism of amyloid …
with diabetes is insulin amyloidosis. Understanding the molecular mechanism of amyloid …
Cirsiliol mitigates Aβ fibrillation and underlying membrane-leakage associated neurotoxicity: A possible implication in the treatment of neurodegenerative disease
H Hu, W Du, W Zhang, J Fang - International Journal of Biological …, 2022 - Elsevier
Protein aggregating is known as a leading pathogenic characteristic of a wide range of
neurodegenerative diseases (NDs). Preventing amyloid-β (Aβ) aggregation and uncovering …
neurodegenerative diseases (NDs). Preventing amyloid-β (Aβ) aggregation and uncovering …
Flavonolignan silibinin abrogates SDS induced fibrillation of human serum albumin
A Basu, S Bhowmick, A Mukherjee - Journal of the Indian Chemical Society, 2022 - Elsevier
Misfolding, aggregation and fibrillation of amyloidogenic proteins have been established as
hallmark events in pathophysiology of various degenerative diseases. Inhibition of protein …
hallmark events in pathophysiology of various degenerative diseases. Inhibition of protein …