Non-obstructive azoospermia (NOA) is the most severe form of male infertility and typically
incurable. Defining the genetic basis of NOA has proven challenging, and the most …

Since 1978, with the first IVF (in vitro fertilization) baby birth in Manchester (England), more
than eight million IVF babies have been born throughout the world, and many new …

Summary Background Primary Ovarian Insufficiency (POI), a public health problem, affects 1-
3.7% of women under 40 yielding infertility and a shorter lifespan. Most causes are …

Although the evolutionary history of the X chromosome indicates its specialization in male
fitness, its role in spermatogenesis has largely been unexplored. Currently only three X …

Infertility affects around 7% of the male population and can be due to severe spermatogenic
failure (SPGF), resulting in no or very few sperm in the ejaculate. We initially identified a …

Einer Infertilität des Mannes liegen häufig anlagebedingte oder erworbene Störungen der
Spermato-und Spermiogenese zugrunde; entsprechende Einschränkungen der …

De novo mutations (DNMs) play an important role in severe genetic disorders that reduce
fitness. To better understand their role in disease, it is important to determine the parent‐of …

Germ cells provide the cellular basis for sexual reproduction in multicellular animals. In
males, germ cells differentiate into sperm, one of the most morphologically diverse …