The resurrection of RIP kinase 1 as an early cell death checkpoint regulator—A potential target for therapy in the necroptosis era
E Ju, KA Park, HM Shen, GM Hur - Experimental & Molecular Medicine, 2022 - nature.com
Receptor-interacting serine threonine protein kinase 1 (RIPK1) has emerged as a central
molecular switch in controlling the balance between cell survival and cell death. The pro …
molecular switch in controlling the balance between cell survival and cell death. The pro …
Pre-Clinical Application of Inhibitor of Apoptosis Protein (IAP) Antagonists in Colorectal Cancer (CRC)
M Meyer - 2022 - repository.rcsi.com
Inhibitor of Apoptosis Proteins (IAPs) have diverse roles in apoptosis, acting as inhibitors of
caspases and mediators of NF-κB signalling. Upregulation of IAPs has been correlated with …
caspases and mediators of NF-κB signalling. Upregulation of IAPs has been correlated with …
Conditional Activation and Synergistic Enhancement of Smac Mimetic Peptides with Nucleic Acids
Y Altrichter - 2022 - edoc.hu-berlin.de
Smac mimetic compounds (SMCs) are a class of tetrapeptide-derived drugs, modelled after
the homodimeric, pro-apoptotic protein Smac. They bind and antagonize Inhibitor of …
the homodimeric, pro-apoptotic protein Smac. They bind and antagonize Inhibitor of …