The traditional view of chronic obstructive pulmonary disease (COPD) as a self-inflicted
disease caused by tobacco smoking in genetically susceptible individuals has been …

Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …

DNA methylation data have become a valuable source of information for biomarker
development, because, unlike static genetic risk estimates, DNA methylation varies …

With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …

Obesity is in theory defined on the basis of the excess health risk caused by adiposity
exceeding the size normally found in the population, but for practical reasons, the World …

Environmental exposures during early life play a critical role in life-course health, yet the
molecular phenotypes underlying environmental effects on health are poorly understood. In …

Imprinted genes–critical for growth, metabolism, and neuronal function–are expressed from
one parental allele. Parent-of-origin-dependent CpG methylation regulates this expression …

Assisted reproductive technology (ART) may affect fetal development through epigenetic
mechanisms as the timing of ART procedures coincides with the extensive epigenetic …

Sedentary lifestyle and consumption of high-calorie foods have caused a relentless increase
of overweight and obesity prevalence at all ages. Its presently epidemic proportion is …

Investigation of gene‐environment interactions (GxE) may provide important insights into the
gene regulatory framework in response to environmental factors of relevance for childhood …