Ex vivo engineered human plasma cells exhibit robust protein secretion and long-term engraftment in vivo

RYH Cheng, KL Hung, T Zhang, CM Stoffers… - Nature …, 2022 - nature.com
Due to their unique longevity and capacity to secrete high levels of protein, plasma B cells
have the potential to be used as a cell therapy for protein replacement. Here, we show that …

Bone marrow derived long-lived plasma cell phenotypes are heterogeneous and can change in culture

SS Mujtahedi, F Yigitbilek, X Benavides… - Transplant …, 2022 - Elsevier
Bone marrow-derived long-lived plasma cells (LLPCs) are thought to be a major source of
alloantibody in sensitized transplant patients. However, studies of LLPCs have been …

[PDF][PDF] The role of the TRK-fused gene (TFG) in B cell differentiation and plasma cell homeostasis

T Steinmetz - 2022 - opus4.kobv.de
Long lasting immunological memory is among the most important functions of the
mammalian immune system. Especially specific neutralizing antibodies from antibody …

[图书][B] Modeling the longevity and secretory capacity of engineered human plasma cells

RYH Cheng - 2022 - search.proquest.com
Due to their unique longevity and capacity to secrete high levels of protein, plasma cells
have the potential to be used as a cell therapy for protein replacement. Through CITE-seq …

[PDF][PDF] Rituximab Therapy in Idiopathic Inflammatory Myositis

N Saar, MD Katalin Dankό - academia.edu
Idiopathic inflammatory myopathies (IIM) is a chronic/sub-acute heterogenic group of
diseases that affects striated muscles tissue. Although the etiology is unknown, IIM like most …