Increased interest in the trifluoromethoxy group in organic synthesis and medicinal
chemistry has induced a demand for new, selective, general, and faster methods applicable …

A simple and efficient construction of 2-difluoro-2, 3-dihydrofurans is reported, which
features metal-free and additive-free conditions, high functional group tolerance and readily …

An unprecedented difluorocarbene-mediated C–O bond cleavage of cyclic ethers for the
construction of difluoromethyl ethers is herein disclosed. This protocol is distinguished by its …

Difluoromethoxyarene moieties have been demonstrated to impart desirable physio-
chemical properties to organic molecules. Presented herein is a shelf-stable radical …

The gem‐difluoroalkene moiety has attracted considerable attention from the synthetic
chemistry community due to its outstanding performance in the drug design and …

摘要开发了一种性状稳定且易于放大合成规模的一氟甲基化试剂——一氟代苯磺酸甲酯(
PhSO3CH2F). 该试剂能够与乙酰丙酮衍生物反应, 在温和条件下以高选择性和良好的收率得到 …

A new shelf-stable and easily scalable monofluoromethylating reagent, fluoromethyl
benzenesulfonate (PhSO 3 CH 2 F), was developed. This reagent is able to react with …