Depletion and dysfunction of dendritic cells: understanding SARS-CoV-2 infection

T Chang, J Yang, H Deng, D Chen, XP Yang… - Frontiers in …, 2022 - frontiersin.org
Uncontrolled severe acute respiratory syndrome-coronavirus (SARS-CoV)-2 infection is
closely related to disorders of the innate immune and delayed adaptive immune systems …

Dendritic cell-based vaccines against cancer: challenges, advances and future opportunities

C Fu, T Ma, L Zhou, QS Mi, A Jiang - Immunological investigations, 2022 - Taylor & Francis
As the most potent professional antigen presenting cells, dendritic cells (DCs) have the
ability to activate both naive CD4 and CD8 T cells. Recognized for their exceptional ability to …

Imaging dendritic cell functions

B Bošnjak, KTH Do, R Förster… - Immunological …, 2022 - Wiley Online Library
Dendritic cells (DCs) are crucial for the appropriate initiation of adaptive immune responses.
During inflammation, DCs capture antigens, mature, and migrate to lymphoid tissues to …

Depletion of conventional type-1 dendritic cells in established tumors suppresses immunotherapy efficacy

A Teijeira, S Garasa, C Luri-Rey, C De Andrea, M Gato… - Cancer research, 2022 - AACR
The ability of conventional type-1 dendritic cells (cDC1) to cross-present tumor antigens to
CD8+ T cells is critical for the induction of antitumor CTLs. Mice that are constitutively …

Pathological and protective roles of dendritic cells in Mycobacterium tuberculosis infection: Interaction between host immune responses and pathogen evasion

H Kim, SJ Shin - Frontiers in Cellular and Infection Microbiology, 2022 - frontiersin.org
Dendritic cells (DCs) are principal defense components that play multifactorial roles in
translating innate immune responses to adaptive immunity in Mycobacterium tuberculosis …

Single-cell transcriptional profiling informs efficient reprogramming of human somatic cells to cross-presenting dendritic cells

FF Rosa, CF Pires, I Kurochkin, E Halitzki… - Science …, 2022 - science.org
Type 1 conventional dendritic cells (cDC1s) are rare immune cells critical for the induction of
antigen-specific cytotoxic CD8+ T cells, although the genetic program driving human cDC1 …

Trafficking and retention of protein antigens across systems and immune cell types

TA Doan, T Forward, BAJ Tamburini - Cellular and Molecular Life Sciences, 2022 - Springer
In response to infection or vaccination, the immune system initially responds non-specifically
to the foreign insult (innate) and then develops a specific response to the foreign antigen …

Conventional type 1 dendritic cells (cDC1) as cancer therapeutics: challenges and opportunities

P Johnson, N Rosendahl… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction The use of dendritic cell (DC)-based cancer vaccines over three decades has
shown them to be a safe therapeutic approach against a range of hematological and solid …

Toward establishing an ideal adjuvant for non-inflammatory immune enhancement

T Seya, M Tatematsu, M Matsumoto - Cells, 2022 - mdpi.com
The vertebrate immune system functions to eliminate invading foreign nucleic acids and
foreign proteins from infectious diseases and malignant tumors. Because pathogens and …

Applications of antibody-based antigen delivery targeted to dendritic cells in vivo

J Bourque, D Hawiger - Antibodies, 2022 - mdpi.com
Recombinant immunoglobulins, derived from monoclonal antibodies recognizing the
defined surface epitopes expressed on dendritic cells, have been employed for the past two …