Immunotherapy including immune checkpoint inhibitors (ICIs) has become the backbone of
treatment for most lung cancers with advanced or metastatic disease. In addition, they have …

Testing peripheral blood for circulating tumor DNA (ctDNA) offers a minimally invasive
opportunity to diagnose, characterize, and monitor the disease in individual cancer patients …

Triple negative breast cancer (TNBC) with easy metastasis,“cold” tumor immune
microenvironment, and lack of targeted therapy remains poorly prognosed. Chemo …

Cyclic dinucleotides (CDNs) as stimulator of interferon genes (STING) agonists capable of
inducing strong antitumor innate immune response are highly promising for tumor …

Background Chimeric antigen receptor (CAR) T cells directed against CD19 (CART19) are
effective in B-cell malignancies, but little is known about the molecular factors predicting …

DNA methylation is a highly regulated process that has a critical role in human development
and homeostatic control of the cell. The number of genes affected by anomalous DNA …

Aberrant methylation of genomic DNA has been reported in many cancers. Specific DNA
methylation patterns have been shown to provide clinically useful prognostic information …

Small cell lung cancer (SCLC) is a particular subtype of lung cancer with high mortality.
Recent advances in understanding SCLC genomics and breakthroughs of immunotherapy …

Adoptive cell therapy (ACT) constitutes a major breakthrough in cancer management that
has expanded in the past years due to impressive results showing durable and even …

Lung cancer (LC) and chronic obstructive pulmonary disease (COPD) are two of the most
fatal respiratory diseases, seriously threatening human health and imposing a heavy burden …