The role of the locus coeruleus in shaping adaptive cortical melodies
Neural dynamics are shaped and constrained by the projections of a small nucleus in the
pons: the noradrenergic locus coeruleus (LC). Much like a bow to the brain's violin, activity in …
pons: the noradrenergic locus coeruleus (LC). Much like a bow to the brain's violin, activity in …
Cognitive and neuropsychiatric effects of noradrenergic treatment in Alzheimer's disease: systematic review and meta-analysis
Background Dysfunction of the locus coeruleus-noradrenergic system occurs early in
Alzheimer's disease, contributing to cognitive and neuropsychiatric symptoms in some …
Alzheimer's disease, contributing to cognitive and neuropsychiatric symptoms in some …
Locus coeruleus integrity from 7 T MRI relates to apathy and cognition in Parkinsonian disorders
Background Neurodegeneration in the locus coeruleus (LC) contributes to neuropsychiatric
symptoms in both Parkinson's disease (PD) and progressive supranuclear palsy (PSP) …
symptoms in both Parkinson's disease (PD) and progressive supranuclear palsy (PSP) …
A phase II study repurposing atomoxetine for neuroprotection in mild cognitive impairment
The locus coeruleus is the initial site of Alzheimer's disease neuropathology, with
hyperphosphorylated Tau appearing in early adulthood followed by neurodegeneration in …
hyperphosphorylated Tau appearing in early adulthood followed by neurodegeneration in …
Locus coeruleus shows a spatial pattern of structural disintegration in Parkinson's disease
CF Madelung, D Meder, SA Fuglsang… - Movement …, 2022 - Wiley Online Library
Background Parkinson's disease (PD) causes a loss of neuromelanin‐positive,
noradrenergic neurons in the locus coeruleus (LC), which has been implicated in nonmotor …
noradrenergic neurons in the locus coeruleus (LC), which has been implicated in nonmotor …
[HTML][HTML] Prefrontal cortical connectivity mediates locus coeruleus noradrenergic regulation of inhibitory control in older adults
Response inhibition is a core executive function enabling adaptive behavior in dynamic
environments. Human and animal models indicate that inhibitory control and control …
environments. Human and animal models indicate that inhibitory control and control …
Disordered decision making: a cognitive framework for apathy and impulsivity in huntington's disease
LA Morris, C O'Callaghan, C Le Heron - Movement Disorders, 2022 - Wiley Online Library
A caregiver's all‐too‐familiar narrative‐“He doesn't think through what he does, but mostly
he does nothing.” Apathy and impulsivity, debilitating and poorly understood, commonly co …
he does nothing.” Apathy and impulsivity, debilitating and poorly understood, commonly co …
Noradrenergic deficits contribute to apathy in Parkinson's disease through the precision of expected outcomes
Apathy is a debilitating feature of many neuropsychiatric diseases, that is typically described
as a reduction of goal-directed behaviour. Despite its prevalence and prognostic …
as a reduction of goal-directed behaviour. Despite its prevalence and prognostic …
Role of dopamine and clinical heterogeneity in cognitive dysfunction in Parkinson's disease
Parkinson's disease (PD) is commonly treated with dopaminergic medication, which
enhances some, while impairing other cognitive functions. It can even contribute to impulse …
enhances some, while impairing other cognitive functions. It can even contribute to impulse …
New approaches for the quantification and targeting of noradrenergic dysfunction in Alzheimer's disease
M David, PA Malhotra - Annals of Clinical and Translational …, 2022 - Wiley Online Library
There is clear, early noradrenergic dysfunction in Alzheimer's disease. This is likely
secondary to pathological tau deposition in the locus coeruleus, the pontine nucleus that …
secondary to pathological tau deposition in the locus coeruleus, the pontine nucleus that …