The construction of the brain relies on a series of well-defined genetically and experience-or
activity-dependent mechanisms which allow to adapt to the external environment. Disruption …

Parvalbumin is a calcium-binding protein present in inhibitory interneurons that play an
essential role in regulating many physiological processes, such as intracellular signaling …

Mesial temporal lobe epilepsy (MTLE) is the most common type of focal refractory epilepsy
and is characterized by recurring seizures that are often refractory to medication. Since …

Seizure initiation is the least understood and most disabling element of epilepsy. Studies of
ictogenesis require high speed recordings at cellular resolution in the area of seizure onset …

We report that increasing inhibition from the basal ganglia (BG) to the superior colliculus
(SC) through the substantia nigra pars reticulata (nigra) using in vivo optogenetic activation …

Under physiological conditions, neuronal network synchronization leads to different
oscillatory EEG patterns that are associated with specific behavioral and cognitive functions …

The mechanisms determining ictal discharge (ID) propagation are still not clear. In the
present study, we aimed to examine these mechanisms in animal and mathematical models …

Aminopyridine (4-AP) induces ictal-like epileptiform discharges in a variety of brain regions.
These events are associated with enhanced inhibitory and excitatory synaptic …

Under some pathological conditions, such as pharmacoresistant epilepsy, status epilepticus
or certain forms of genetic abnormalities, spiking activity of GABAergic interneurons may …

The mechanisms underlying the generation of hippocampal epileptic seizures and interictal
events and their interactions with the sleep-wake cycle are not yet fully understood. Indeed …