Tumour-associated macrophages are an essential component of the tumour
microenvironment and have a role in the orchestration of angiogenesis, extracellular matrix …

As an essential component of immunity, macrophages have key roles in mammalian host
defense, tissue homeostasis, and repair, as well as in disease pathogenesis and …

Altered enteric microorganisms in concert with host genetics shape inflammatory bowel
disease (IBD) phenotypes. However, insight is limited to bacteria and fungi. We found that …

Macrophages and cancer cells populations are posited to navigate basement membrane
barriers by either mobilizing proteolytic enzymes or deploying mechanical forces …

The heart contains a population of resident macrophages that markedly expands following
injury through recruitment of monocytes and through proliferation of macrophages. In …

Fibrosis is a progressive biological condition, leading to organ dysfunction in various clinical
settings. Although fibroblasts and macrophages are known as key cellular players for …

Cancer immunotherapy has tremendous promise, but it has yet to be clinically applied in a
wider variety of tumor situations. Many therapeutic combinations are envisaged to improve …

Macrophages are dynamic immune cells that can adopt several activation states.
Fundamental to these functional activation states is the regulation of cellular metabolic …

Alternatively activated macrophages (M2 polarization) play an important role in asthma.
Short-chain fatty acids (SCFAs) possessed immune-regulatory functions, but their effects on …

Immune checkpoint inhibitors (ICIs), including anti-programmed cell death-1/anti-
programmed cell death ligand-1 (anti-PD-1/PD-L1) therapy, have elicited impressive clinical …