Hypertension affects over a billion adults worldwide and is one of the leading causes of
premature death. 1 In younger children, most hypertension is secondary but primary …

Manganese (Mn) is an essential trace element required for various biological processes.
However, excess Mn causes serious side effects in humans, including parkinsonism. Thus …

Objectives Physical inactivity and sedentary behaviour are associated with higher breast
cancer risk in observational studies, but ascribing causality is difficult. Mendelian …

Aortic dimensions and distensibility are key risk factors for aortic aneurysms and dissections,
as well as for other cardiovascular and cerebrovascular diseases. We present genome-wide …

Asthma is a complex disease that varies widely in prevalence across populations. The
extent to which genetic variation contributes to these disparities is unclear, as the genetics …

A key aim in epidemiological neuroscience is identification of markers to assess brain health
and monitor therapeutic interventions. Quantitative susceptibility mapping (QSM) is an …

In a multi-stage analysis of 52,436 individuals aged 17-90 across diverse cohorts and
biobanks, we train, test, and evaluate a polygenic risk score (PRS) for hypertension risk and …

Background Circulating levels of amino acids were associated with blood pressure (BP) in
observational studies. However, the causation of such associations has been hypothesized …

Background and Objectives Migraine, stroke, and cervical artery dissection (CeAD)
represent a triad of cerebrovascular disorders with pairwise comorbid relationships and …

Hypertension is a major cardiovascular disease risk factor and contributor to premature
death globally. Family-based investigations confirmed a significant heritable component of …