Exploring the Predictive Power of the In Situ Perfusion Technique towards Drug Absorption: Theory, Practice, and Applications
B Hens, I Gonzalez-Alvarez… - Molecular Pharmaceutics, 2022 - ACS Publications
Considering the broad applications and popularity, the in situ perfusion technique is an
established and interesting approach to evaluate the absorption mechanisms of drug …
established and interesting approach to evaluate the absorption mechanisms of drug …
Modification of the interfacial structure of droplet-stabilised emulsions during in vitro dynamic gastric digestion: Impact on in vitro intestinal lipid digestion
The in-vitro gastrointestinal digestion behaviour of an oil-in-water emulsion with an interface
consisting of nano-sized droplets coated with caseinate particles, referred to as a droplet …
consisting of nano-sized droplets coated with caseinate particles, referred to as a droplet …
[HTML][HTML] Combining lipid based drug delivery and amorphous solid dispersions for improved oral drug absorption of a poorly water-soluble drug
GI Nora, R Venkatasubramanian, S Strindberg… - Journal of Controlled …, 2022 - Elsevier
Two widely applied enabling drug delivery approaches, self-nanoemulsifying drug delivery
systems (SNEDDS) and amorphous solid dispersions (ASD), were combined, with the aim of …
systems (SNEDDS) and amorphous solid dispersions (ASD), were combined, with the aim of …
[HTML][HTML] Solidification of self-emulsifying drug delivery systems as a novel approach to the management of uncomplicated malaria
EB Seo, LH du Plessis, JM Viljoen - Pharmaceuticals, 2022 - mdpi.com
Malaria affects millions of people annually, especially in third-world countries. The mainstay
of treatment is oral anti-malarial drugs and vaccination. An increase in resistant strains of …
of treatment is oral anti-malarial drugs and vaccination. An increase in resistant strains of …
Supersaturable self-emulsifying drug delivery system: a strategy for improving the loading and oral bioavailability of quercetin
Supersaturable Lipid based drug delivery systems have gained much attention as bio-
enabling formulation approach for oral delivery of drugs with high dose. Hence, the present …
enabling formulation approach for oral delivery of drugs with high dose. Hence, the present …
[HTML][HTML] Digestion of lipid excipients and lipid-based nanocarriers by pancreatic lipase and pancreatin
The digestion behaviour of lipid-based nanocarriers (LNC) has a great impact on their oral
drug delivery properties. In this study, various excipients including surfactants, glycerides …
drug delivery properties. In this study, various excipients including surfactants, glycerides …
The digestion of diacylglycerol isomers by gastric and pancreatic lipases and its impact on the metabolic pathways for TAG re-synthesis in enterocytes
JC Bakala-N'Goma, L Couëdelo, C Vaysse, M Letisse… - Biochimie, 2022 - Elsevier
The specific activities of gastric and pancreatic lipases were measured using triacylglycerols
(TAG) from rapeseed oil, purified 1, 3-sn-DAG and 1, 2 (2, 3)-sn-DAG produced from this oil …
(TAG) from rapeseed oil, purified 1, 3-sn-DAG and 1, 2 (2, 3)-sn-DAG produced from this oil …
Formulation, characterization and in-vitro evaluation of self-nanoemulsifying drug delivery system containing rhamnolipid biosurfactant
Self-nanoemulsifying drug delivery systems (SNEDDS) are most commonly used lipid-
based drug delivery systems for bioavailability enhancement. Mostly SNEDDS contains high …
based drug delivery systems for bioavailability enhancement. Mostly SNEDDS contains high …
[HTML][HTML] Biocompatible cationic lipoamino acids as counterions for oral administration of API-ionic liquids
Purpose The use of ionic liquids (ILs) in drug delivery has focused attention on non-toxic IL
counterions. Cationic lipids can be used to form ILs with weakly acidic drugs to enhance …
counterions. Cationic lipids can be used to form ILs with weakly acidic drugs to enhance …
[HTML][HTML] UNGAP best practice for improving solubility data quality of orally administered drugs
M Vertzoni, J Alsenz, P Augustijns… - European Journal of …, 2022 - Elsevier
An important goal of the European Cooperation in Science and Technology (COST) Action
UNGAP (UNderstanding Gastrointestinal Absorption-related Processes, www. ungap. eu) is …
UNGAP (UNderstanding Gastrointestinal Absorption-related Processes, www. ungap. eu) is …