Innate immune mechanisms initiate immune responses via pattern-recognition receptors
(PRRs). Cyclic GMP-AMP synthase (cGAS), a member of the PRRs, senses diverse …

Gammaherpesviruses are ubiquitous pathogens that establish lifelong infections in the vast
majority of adults worldwide. Importantly, these viruses are associated with numerous …

Gammaherpesviruses, such as Epstein-Barr virus and Kaposi's sarcoma-associated
herpesvirus, are important human pathogens involved in lymphoproliferative disorders and …

Marek's disease virus (MDV) is a highly oncogenic alphaherpesvirus that induces malignant
T-cell lymphomas in chickens, leading to great economic loss in poultry industry. The unique …

Upon infection, the herpes viruses create a cellular environment suitable for survival, but
innate immunity plays a vital role in cellular resistance to viral infection. The UL13 protein of …

We have formerly identified the conserved herpesvirus protein kinase (CHPK) as essential
for horizontal transmission of Marek's disease virus (MDV). Thus far, it has been confirmed …

Gammaherpesviruses infect most vertebrate species and are associated with B cell
lymphomas. Manipulation of B cell differentiation is critical for natural infection and …

Gammaherpesviruses establish lifelong infections in most vertebrate species, including
humans and rodents, and are associated with cancers, including B cell lymphomas. While …

Epstein-Barr Virus (EBV) known as human gammaherpesvirus is latently present in more
than 95% of the world adult population. The virus undergoes lytic replication and latent cycle …

1. Hintergrund Inteferon lambda (IFNL) wurde im Jahr 2003 erstmals beschrieben und
gehört zur Zytokinfamilie der Interferone. Im menschlichen Körper entfaltet es vor allem in …